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Southern Illinois University School of Medicine

5 ARTICLES PUBLISHED IN JoVE

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Bioengineering

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Ashim Gupta 1, Kevin Sharif 2, Megan Walters 2, Mia D. Woods 1, Anish Potty 2, Benjamin J. Main 4, Saadiq F. El-Amin III 1,2,3
1Department of Medical Microbiology, Immunology & Cell Biology, Southern Illinois University School of Medicine, 2Division of Orthopaedics and Rehabilitation, Department of Surgery, Southern Illinois University School of Medicine, 3Department of Electrical and Computer Engineering, Biomedical Engineering Program, Southern Illinois University Carbondale, 4University of Illinois at Springfield

For future applications as a patch to repair partial tears of the Anterior Cruciate Ligament (ACL), human ACL derived cells were isolated from tissue obtained during reconstructive procedures, expanded in vitro and grown on tissue engineered scaffolds. Cellular adhesion and morphology was then performed to confirm biocompatibility on scaffold surface.

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Medicine

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Ayman I. Omar 1
1Southern Illinois University School of Medicine

A novel methodology that is employed for the treatment of recurrent glioblastomas is described. This treatment approach employs the application of alternating electric tumor treating fields (TTFields), known as TTF Therapy in combination with bevacizumab, a targeted agent that is currently FDA approved as monotherapy.

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Cancer Research

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Katherine A. Murphy *1,2, Britnie R. James *1,2,3, Andrew Wilber 4,5, Thomas S. Griffith 1,2,3
1Department of Urology, University of Minnesota, 2Masonic Cancer Center, University of Minnesota, 3Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, 4Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 5Simmons Cancer Institute

Implementation of an orthotopic model of renal cell carcinoma in immunocompetent mice affords the investigator a clinically-relevant system defined by the presence of a primary renal tumor and lung metastases in the same animal. This system can be used to preclinically test a variety of treatments in vivo.

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Medicine

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Kelly Sheehan *1, Sandeep Sheth *2, Debashree Mukherjea 1, Leonard P. Rybak 1,2, Vickram Ramkumar 2
1Department of Surgery, Division of Otolaryngology, Southern Illinois University School of Medicine, 2Department of Pharmacology, Southern Illinois University School of Medicine

We present a technique for localized administration of drugs through the trans-tympanic route into the cochlea. Drug delivery through this route would not interfere with the anti-cancer efficacy of the chemotherapeutic drugs such as cisplatin.

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Environment

A Set of In Situ Informed Simulated Medium Formats for Culturing Environmentally Acquired Anaerobic Microorganisms
Tia Zimmerman 1, Garion Leamon 1, Georgia Dillenburg 1, Bethany Egge 1, Jennifer Pierce 2, Ben Elliott 3, Trevor Murphy 1, Marjorie Brooks 4, Scott D. Hamilton-Brehm 1
1Department of Microbiology, Southern Illinois University Carbondale, 2MEDPREP, Southern Illinois University School of Medicine, 3Department of Geology, Southern Illinois University Carbondale, 4Department of Zoology, Southern Illinois University Carbondale

The focus of this paper is to detail best practices for making media for fastidious anaerobic microorganisms acquired from an environment. These methods help manage anaerobic cultures and can be applied to support the growth of elusive uncultured microorganisms, the "microbial dark matter."

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