Sign In

University of Connecticut Health Center & Connecticut Children's Medical Center

1 ARTICLES PUBLISHED IN JoVE

image

Bioengineering

Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue
Karolina Chwalek 1, Disha Sood 1, William L. Cantley 1, James D. White 1, Min Tang-Schomer 2, David L. Kaplan 1
1Department of Biomedical Engineering, Tufts University, 2Department of Pediatrics, University of Connecticut Health Center & Connecticut Children's Medical Center

Insight into the complex actions of the brain requires advanced research tools. Here we demonstrate a novel silk-collagen-based 3D engineered model of neural tissue resembling brain-like architecture. The model can be used to study neuronal network assembly, axonal guidance, cell-cell interactions and electrical activity.

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved