Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney InjuryNatalie Burkard 1, Wolfgang Baar 2,3, Sven Flemming 1, Nicolas Schlegel 1, Jakob Wollborn 2,3, Reinhard Schneider 4, Robert W Brock 5, Christian Wunder 6, Martin Alexander Schick 2,3
1Department of General, Visceral, Transplantation, Vascular and Paediatric Surgery, Department of Surgery I, University of Würzburg, 2Department of Anesthesiology and Critical Care, Medical Center-University of Freiburg, 3Faculty of Medicine, University of Freiburg, 4Department of Internal Medicine I, Division of Nephrology, University of Würzburg, 5Department of Physiology and Pharmacology, West Virginia University School of Medicine, Robert C. Byrd Health Science Center, 6Department of Anesthesiology and Intensive Care Medicine, Robert-Bosch-Krankenhaus
Acute kidney injury (AKI) is a severe complication in critically ill patients and is related with an increased mortality. Here, we present a reliable and reproducible in vivo model to mimic AKI under inflammatory conditions that might contribute towards understanding the pathogenesis of septic AKI.
