Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human SerumAbhijeet Patra 1, Tao Ding 2, Minghui Hong 3, Arthur Mark Richards 2, Ten It Wong 4, Xiaodong Zhou 4, Chester Lee Drum 2
1NUS Nanoscience and Nanotechnology Initiative, National University of Singapore, 2Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, 3Department of Electrical and Computer Engineering, National University of Singapore, 4Institute of Materials Research Engineering, A*STAR (Agency for Science, Technology and Research)
This work describes a nanoimprinting lithography method to fabricate high-quality sensing arrays that work on the principle of extraordinary optical transmission. The biosensor is low-cost, robust, easy to use, and can detect cardiac troponin I in serum at clinically relevant concentrations (99th percentile cutoff ∼10-400 pg/mL, depending on the assay).
