Methods for Analyzing the Impacts of Natural Uranium on In Vitro OsteoclastogenesisTatiana Gritsaenko 1, Valérie Pierrefite-Carle 1, Gaëlle Creff 2, Claude Vidaud 3, Georges Carle 1, Sabine Santucci-Darmanin 1
1UMR E-4320 TIRO-MATOs CEA/DRF/BIAM, Université Nice Sophia-Antipolis, 2UMR 7272 Institut de Chimie de Nice CNRS, Université Nice Sophia-Antipolis, 3CEA, Direction de la Recherche Fondamentale (DRF), Biosciences and Biotechnologies Institute (BIAM)
Uranium is known to affect bone metabolism. Here, we present a protocol aimed at investigating the effect of natural uranium exposure on the viability, the differentiation, and the function of osteoclasts, the cells in charge of bone resorption.
