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Harvard Medical School - Beth Israel Deaconess Medical Center

2 ARTICLES PUBLISHED IN JoVE

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Behavior

Mimicking a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats
Marie Mortreux 1, Daniela Riveros 1, Mary L. Bouxsein 2, Seward B. Rutkove 1
1Department of Neurology, Harvard Medical School - Beth Israel Deaconess Medical Center, 2Department of Orthopaedics, Harvard Medical School - Beth Israel Deaconess Medical Center

By using an innovative ground-based analogue model, we are able to simulate a space mission including a trip to (0 g) and a stay on Mars (0.38 g) in rats. This model allows for a longitudinal assessment of the physiological changes occurring during the two hypo-gravitational stages of the mission.

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Biology

Performing In Vivo and Ex Vivo Electrical Impedance Myography in Rodents
Marie Mortreux 1, Janice A. Nagy 1, Haowen Zhong 1, Dong-Min Sung 1, Holly A. Concepcion 1, Melanie Leitner 2, Laura Dalle Pazze 3, Seward B. Rutkove 1
1Department of Neurology, Harvard Medical School - Beth Israel Deaconess Medical Center, 2Accelerating NeuroVentures, 3Charley's Fund

This article details how to perform in vivo (using surface and needle electrode arrays) and ex vivo (using a dielectric cell) electrical impedance myography on the rodent gastrocnemius muscle. It will demonstrate the technique in both mice and rats and detail the modifications available, (i.e., obese animals, pups).

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