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Centro Hospitalar Universitário Lisboa Norte

3 ARTICLES PUBLISHED IN JoVE

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Medicine

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
Augusto Ministro 1,2, Paula de Oliveira 1, Raquel J. Nunes 1, André dos Santos Rocha 1, Tiago Ferreira 2, J. Goyri-O'Neill 3, Susana Constantino Rosa Santos 1
1Centro Cardiovascular da Universidade de Lisboa, Lisbon School of Medicine of the Universidade de Lisboa, 2Centro Hospitalar Universitário Lisboa Norte, 3Nova Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa

Here, a critical hindlimb ischemia experimental model is presented followed by a battery of functional, histologic and molecular tests to assess the effectiveness of angiogenic therapies.​

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Medicine

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
Sónia Ribeiro *1,2, Ana Rita S. Pereira *1, Ana Teresa Pinto 1, Filipe Rocha 1, Augusto Ministro 1,2, Manuela Fiuza 1,2, Fausto Pinto 1,2, Susana Constantino Rosa Santos 1
1Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Universidade de Lisboa, 2Departamento Coração e Vasos, Centro Hospitalar Universitário Lisboa Norte

A non-invasive protocol for transthoracic echocardiography assessment of cardiac anatomy and function for adult rats is presented in the current study. The heart valves, all four cardiac chambers and the ascending aorta, aortic arch and descending aorta are studied in detail.

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Medicine

Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model
Pedro S. de Oliveira 1,2, Filipe Rocha 1, Inês Sofia Vala 1, Paula de Oliveira 1, Augusto Ministro 1,3, Susana Constantino Rosa Santos 1
1Cardiovascular Center of the University of Lisbon (CCUL@RISE), Faculdade de Medicina da Universidade de Lisboa, 2Department of Urology, Centro Hospitalar Universitário Lisboa Norte, 3Department of Vascular Surgery, Centro Hospitalar Universitário Lisboa Norte

In the present protocol, a urethral stricture induction was developed in Wistar rats, followed by urethral reconstruction with a buccal mucosa graft. A retrograde urethrogram and laser Doppler assessment were performed, validating urethral reconstruction (after stricture formation) and graft placement.

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