Medicon Pharmaceuticals, Inc.

2 ARTICLES PUBLISHED IN JoVE

Medicine

A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies

Robert A. Honkanen¹, Liqun Huang^2,3, Basil Rigas²

¹Department of Ophthalmology, Stony Brook University, ²Department of Preventive Medicine, Stony Brook University, ³Medicon Pharmaceuticals, Inc.

This article describes the development of a method to induce acute or chronic dry eye disease in rabbits by injecting concanavalin A to all portions of the orbital lacrimal gland system. This method, superior to those already reported, generates a reproducible, stable model of dry eye suitable for the study of pharmacological agents.

Medicine

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Robert A. Honkanen¹, Liqun Huang^2,3, Wei Huang¹, Basil Rigas^2,4

¹Department of Ophthalmology, Stony Brook University, ²Department of Medicine, Stony Brook University, ³Medicon Pharmaceuticals, Inc, ⁴Department of Preventive Medicine, Stony Brook University

A novel approach is presented to induce chronic dry eye disease in rabbits by surgically removing all orbital lacrimal glands. This method, distinct from those previously reported, produces a stable, reproducible model of aqueous deficient dry eye well suited to study tear physiology and pathophysiology and ocular therapeutics.