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2 ARTICLES PUBLISHED IN JoVE

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Chemistry

Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes
Anna N. Ivanovskaya *1, Anna M. Belle *1, Allison Yorita 1, Fang Qian 2, Supin Chen 1, Angela Tooker 1, Rose GarcÍa Lozada 1, Dylan Dahlquist 1, Vanessa Tolosa 1
1Engineering Directorate, Lawrence Livermore National Laboratory, 2Physical and Life Science Directorate, Lawrence Livermore National Laboratory

This protocol demonstrates a method for electrochemical roughening of thin-film platinum electrodes without preferential dissolution at grain boundaries. The electrochemical techniques of cyclic voltammetry and impedance spectroscopy are demonstrated to characterize these electrode surfaces.

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Neuroscience

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
Jason E Chung *1,2, Hannah R Joo *1,2, Clay N Smyth 2, Jiang Lan Fan 3, Charlotte Geaghan-Breiner 2, Hexin Liang 2, Daniel Fan Liu 3, Demetris Roumis 2, Supin Chen 4,5, Kye Y Lee 4, Jeanine A Pebbles 4, Angela C Tooker 4, Vanessa M Tolosa 4,5, Loren M Frank 2,6
1Medical Scientist Training Program and Neuroscience Graduate Program, University of California San Francisco, 2Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Department of Physiology, University of California San Francisco, 3Bioengineering Graduate Program, University of California San Francisco, 4Center for Micro- and Nanotechnology, Lawrence Livermore National Laboratory, 5Neuralink Corp., 6Howard Hughes Medical Institute

Described below is a method for implantation of multiple polymer electrode arrays across anatomically distant brain regions for chronic electrophysiological recording in freely moving rats. Preparation and surgical implantation are described in detail, with emphasis on design principles to guide adaptation of these methods for use in other species.

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