KIST Europe Forschungsgesellschaft mbH

2 ARTICLES PUBLISHED IN JoVE

Bioengineering

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Baeckkyoung Sung^*1,2, Steven Shaffer^*1, Michal Sittek^*1, Talib Alboslemy¹, Chanjoong Kim^2,3, Min-Ho Kim¹

¹Department of Biological Sciences, Kent State University, ²Liquid Crystal Institute, Kent State University, ³Chemical Physics Interdisciplinary Program, Kent State University

We present a facile method to fabricate a biodegradable gelatin-based drug release platform that is magneto-thermally responsive. This was achieved by incorporating superparamagnetic iron oxide nanoparticles and poly(N-isopropylacrylamide-co-acrylamide) within a spherical gelatin micro-network crosslinked by genipin, in conjunction with an alternating magnetic field application system.

Bioengineering

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

Marie-Léonie Bohlen¹, Hyun Pyo Jeon¹, Young Jun Kim¹, Baeckkyoung Sung¹

¹KIST Europe Forschungsgesellschaft mbH

Quantitative structure-activity relationship (QSAR) modeling is a representative bioinformatics-assisted method in toxicological screening. This protocol demonstrates how to computationally assess the risks of endocrine disruptors (EDs) in aquatic environments. Utilizing the OECD QSAR Toolbox, the protocol implements an in silico assay for analyzing toxicity of EDs in fish.