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Instituto de Investigación Sanitaria Gregorio Marañón

3 ARTICLES PUBLISHED IN JoVE

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Medicine

Combining Augmented Reality and 3D Printing to Display Patient Models on a Smartphone
Rafael Moreta-Martinez 1,2, David García-Mato 1,2, Mónica García-Sevilla 1,2, Rubén Pérez-Mañanes 2,3,4, José A. Calvo-Haro 2,3,4, Javier Pascau 1,2
1Department of Bioengineering and Aerospace Engineering, Universidad Carlos III de Madrid, 2Instituto de Investigación Sanitaria Gregorio Marañón, 3Department of Orthopedic Surgery and Traumatology, Hospital General Universitario Gregorio Marañón, 4Department of Surgery, Faculty of Medicine, Universidad Complutense de Madrid

Presented here is a method to design an augmented reality smartphone application for the visualization of anatomical three-dimensional models of patients using a 3D-printed reference marker.

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Bioengineering

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
Ignacio Risueño 1, Leticia Valencia 1, Miguel Holgado 2, Jose L. Jorcano 3, Diego Velasco 1,4
1Department of Bioengineering and Aerospace Engineering, Universidad Carlos III de Madrid (UC3M), 2Group of Optics, Photonics and Biophotonics (GOFB). Center for Biomedical Technology, Universidad Politécnica de Madrid, 3Division of Epithelial Biomedicine, CIEMAT, 4Instituto de Investigación Sanitaria Gregorio Marañón

Here, we present a protocol to generate a three-dimensional simplified and undifferentiated skin model using a micromachined microfluidic platform. A parallel flow approach allows the in situ deposition of a dermal compartment for the seeding of epithelial cells on top, all controlled by syringe pumps.

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Neuroscience

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats
Marta Casquero-Veiga 1, Nicolás Lamanna-Rama 2,3, Diego Romero-Miguel 2,3, Manuel Desco 1,2,3,4, María Luisa Soto-Montenegro 2,4,5
1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 2Laboratorio de Imagen Médica, Instituto de Investigación Sanitaria Gregorio Marañón, 3Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, 4CIBER de Salud Mental (CIBERSAM), 5High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut), Universidad Rey Juan Carlos

We describe a preclinical experimental method to evaluate metabolic neuromodulation induced by acute deep brain stimulation with in vivo FDG-PET. This manuscript includes all experimental steps, from stereotaxic surgery to the application of the stimulation treatment and the acquisition, processing, and analysis of PET images.

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