Instituto de Investigación Sanitaria Gregorio Marañón

3 ARTICLES PUBLISHED IN JoVE

Medicine

Combining Augmented Reality and 3D Printing to Display Patient Models on a Smartphone

Rafael Moreta-Martinez^1,2, David García-Mato^1,2, Mónica García-Sevilla^1,2, Rubén Pérez-Mañanes^2,3,4, José A. Calvo-Haro^2,3,4, Javier Pascau^1,2

¹Department of Bioengineering and Aerospace Engineering, Universidad Carlos III de Madrid, ²Instituto de Investigación Sanitaria Gregorio Marañón, ³Department of Orthopedic Surgery and Traumatology, Hospital General Universitario Gregorio Marañón, ⁴Department of Surgery, Faculty of Medicine, Universidad Complutense de Madrid

Presented here is a method to design an augmented reality smartphone application for the visualization of anatomical three-dimensional models of patients using a 3D-printed reference marker.

Bioengineering

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Ignacio Risueño¹, Leticia Valencia¹, Miguel Holgado², Jose L. Jorcano³, Diego Velasco^1,4

¹Department of Bioengineering and Aerospace Engineering, Universidad Carlos III de Madrid (UC3M), ²Group of Optics, Photonics and Biophotonics (GOFB). Center for Biomedical Technology, Universidad Politécnica de Madrid, ³Division of Epithelial Biomedicine, CIEMAT, ⁴Instituto de Investigación Sanitaria Gregorio Marañón

Here, we present a protocol to generate a three-dimensional simplified and undifferentiated skin model using a micromachined microfluidic platform. A parallel flow approach allows the in situ deposition of a dermal compartment for the seeding of epithelial cells on top, all controlled by syringe pumps.

Neuroscience

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats

Marta Casquero-Veiga¹, Nicolás Lamanna-Rama^2,3, Diego Romero-Miguel^2,3, Manuel Desco^1,2,3,4, María Luisa Soto-Montenegro^2,4,5

¹Centro Nacional de Investigaciones Cardiovasculares (CNIC), ²Laboratorio de Imagen Médica, Instituto de Investigación Sanitaria Gregorio Marañón, ³Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, ⁴CIBER de Salud Mental (CIBERSAM), ⁵High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut), Universidad Rey Juan Carlos

We describe a preclinical experimental method to evaluate metabolic neuromodulation induced by acute deep brain stimulation with in vivo FDG-PET. This manuscript includes all experimental steps, from stereotaxic surgery to the application of the stimulation treatment and the acquisition, processing, and analysis of PET images.