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University Medical Center Rostock

4 ARTICLES PUBLISHED IN JoVE

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Medicine

Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse
Daniel Strüder *1, Eberhard Grambow *2, Ernst Klar 2, Robert Mlynski 1, Brigitte Vollmar 3
1Department of Otorhinolaryngology, Head and Neck Surgery "Otto Koerner", Rostock University Medical Center, 2Department of General, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center, 3Institute for Experimental Surgery, Rostock University Medical Center

The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.

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Medicine

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
Christian Klopsch 1, Alexander Kaminski 1, Friedrich Prall 2, Pascal Dohmen 1,3
1Department of Cardiac Surgery, Heart Center Rostock, Rostock University Medical Center, University of Rostock, 2Institute of Pathology, Rostock University Medical Center, University of Rostock, 3Department of Cardiothoracic Surgery, Faculty of Health Science, University of the Free State

Presented here is a protocol for antegrade endoscopic vein harvesting from the lower leg, which can safely be introduced in routine coronary artery bypass grafting. Vein grafts present excellent graft quality following this standardized protocol with positioning of the legs, minimally invasive access to the vein, and antegrade endoscopic vein harvesting.

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Medicine

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Nora M. Weiss 1, Ingo Andus 2, Armin Schneider 3, Sönke Langner 4, Stefanie Schröder 1, Sebastian P. Schraven 1, Robert Mlynski 1
1Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Rostock, 2Rostock University, 3ARRI Medical GmbH, 4Department of Radiology and Institute of Diagnostic and Interventional Radiology, University Medical Center Rostock

Intrathecally applied fluorescein is used to achieve intraoperative visualization of CSF leaks. This protocol describes a lumbar puncture, the application of 5% fluorescein, and intraoperative visualization using a fully digital microscope.

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Cancer Research

Creation and Maintenance of a Living Biobank - How We Do It
Florian Bürtin 1, Stephanie Matschos 2, Friedrich Prall 3, Christina S. Mullins 2, Mathias Krohn 2, Michael Linnebacher 2
1Department of General, Visceral, Vascular and Transplantation Surgery, University Medical Center Rostock, University of Rostock, 2Molecular Oncology and Immunotherapy, Department of General, Visceral, Vascular and Transplantation Surgery, University Medical Center Rostock, 3Institute of Pathology, University Medical Center Rostock

In the following work, we describe the consecutive steps necessary for the establishment of a large biobank of colorectal and pancreatic cancer.

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