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Weill Cornell Medicine, New York, NY

1 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

Performing Colonoscopic-Guided Pinch Biopsies in Mice and Evaluating Subsequent Tissue Changes
David C. Montrose 1,2, Erin M. McNally 3, Erika Sue 3, Andrew J. Dannenberg 3
1Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 2Stony Brook Cancer Center, Stony Brook, NY, 3Department of Medicine, Weill Cornell Medicine, New York, NY

Here, we provide a detailed description of the procedure to induce colonoscopic-guided pinch biopsies in mice and track wound closure in real time. Additionally, methods for the preparation of tissues for histological, immunohistochemical and molecular analyses of the wound bed are provided.

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