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Cancer Center Amsterdam

8 ARTICLES PUBLISHED IN JoVE

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Medicine

Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis
Alberto Balduzzi *1,2, Maurice J. W. Zwart *1, Rens M. A. Kempeneers 1, Marja A. Boermeester 1, Olivier R. Busch 1, Marc G. Besselink 1
1Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, 2General and Pancreatic Surgery Department, Pancreas Institute, University and Hospital Trust of Verona

Robotic lateral pancreaticojejunostomy (RLPJ) may be used in patients with painful, morphine dependent, chronic pancreatitis and a dilated main pancreatic duct. We describe a standardized and reproducible technique for RLPJ, which includes transection of the gastroduodenal artery.

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Medicine

DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
Sanne Lof 1, Rushda Rajak 2, Frederique L. I. M. Vissers 3, Maarten Korrel 3, Adrian Bateman 2, Johanna Verheij 4, Caroline Verbeke 5, Ivana Cataldo 6, Marc G. Besselink 3, Mohammed Abu Hilal 1
1Department of Surgery, Southampton University Hospital NHS Foundation Trust, 2Department of Pathology, Southampton University Hospital NHS Foundation Trust, 3Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, 4Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, 5Department of Pathology, Oslo University Hospital & University of Oslo, 6Department of Pathology, Ca Foncello Hospital

The current study highlights a standardized approach to the macroscopic assessment of distal pancreatectomy specimens for pancreatic ductal adenocarcinoma, with special emphasis on the measurement of pancreatic dimensions and those of other organs, inking of margins, measurement of tumor size and proximity to margins, lymph node sampling and block selection.

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Neuroscience

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
Rianne Haumann *1,2, Elvin ’t Hart *2, Marc P. P. Derieppe 2, Helena C. Besse 3, Gertjan J. L. Kaspers 1,2, Eelco Hoving 2, Dannis G. van Vuurden 1,2, Esther Hulleman 1,2, Mario Ries 3
1Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Oncology, Cancer Center Amsterdam, 2Princess Máxima Center for Pediatric Oncology, 3Imaging Division, Utrecht University

The blood-brain barrier (BBB) can be temporarily disrupted with microbubble-mediated focused ultrasound (FUS). Here, we describe a step-by-step protocol for high-throughput BBB opening in vivo using a modular FUS system accessible for non-ultrasound experts.

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Medicine

Robotic Central Pancreatectomy with Roux-en-Y Pancreaticojejunostomy
Tess M.E. van Ramshorst 1, Maurice J.W. Zwart 1, Rogier P. Voermans 2, Sebastiaan Festen 3, Freek Daams 4, Olivier R. Busch 1, Matthijs W.N. Oomen 5, Marc G. Besselink 1, 1
1Department of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, 2Department of Gastroenterology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, 3Department of Surgery, OLVG, 4Department of Surgery, Amsterdam UMC, Vrije Universiteit, 5Department of Pediatric Surgery, Amsterdam UMC, Emma Children's Hospital

Robotic central pancreatectomy may be used in selected patients in experienced centers. This protocol presents all steps and the feasibility of a robotic central pancreatectomy with Roux-en-Y pancreaticojejunostomy in a 16-year-old adolescent patient.

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Cancer Research

Robotic Pancreatoduodenectomy for Pancreatic Head Cancer: a Case Report of a Standardized Technique
Maurice J. W. Zwart *1,2, Leia R. Jones *1,2,3, Melissa E. Hogg 4, Johanna A. M. G. Tol 1,2, Mohammad Abu Hilal 3, Freek Daams 5, Sebastiaan Festen 6, Olivier R. Busch 1,2, Marc G. Besselink 1,2,
1Department of Surgery, Amsterdam, the Netherlands, Amsterdam UMC, location University of Amsterdam, 2Cancer Center Amsterdam, the Netherlands, 3Department of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza, 4Department of Surgery, Northshore University Health System, 5Department of Surgery, Amsterdam UMC, Vrije Universiteit, Cancer Center Amsterdam, 6Department of Surgery, OLVG

Robotic pancreatoduodenctomy (RPD) has been highly standardized in recent years and may be used in selected patients with pancreatic head cancer, including those with a replaced right hepatic artery. This case report describes a standardized and reproducible technique for RPD, which includes the approach of the Dutch LAELAPS-3 training program to an aberrant vasculature.

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Medicine

Robotic Left Hepatectomy using Indocyanine Green Fluorescence Imaging for an Intrahepatic Complex Biliary Cyst
Burak Görgec 1,2, Babs M. Zonderhuis 2,3, Marc G. Besselink 1,2, Joris Erdmann 1,2,3, Geert Kazemier 2,3, Rutger-Jan Swijnenburg 1,2,3
1Department of Surgery, Amsterdam UMC, location University of Amsterdam, 2Cancer Center Amsterdam, 3Department of Surgery, Amsterdam UMC, location Vrije Universiteit

Robotic liver surgery has gained more acceptance as a feasible, safe, and effective procedure for the treatment of both benign and malignant indications. However, robotic left hepatectomy is still technically demanding. We describe our surgical technique of a robotic left hepatectomy using indocyanine green fluorescence imaging for a large biliary cyst.

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Robotic Spleen-Preserving Distal Pancreatectomy: The Warshaw and Kimura Techniques

Robotic Spleen-Preserving Distal Pancreatectomy: The Warshaw and Kimura Techniques
Evgenia Kotsifa 1,2,3, Sebastiaan Festen 4, Olivier R. Busch 1,3, Marc G. Besselink 1,3, Freek Daams 2,3,
1Department of Surgery, Amsterdam UMC, location University of Amsterdam, 2Department of Surgery, Amsterdam UMC, location Vrije Universiteit, 3Cancer Center Amsterdam, 4Department of Surgery, OLVG

Here, we present a step-by-step protocol of robotic spleen preserving distal pancreatectomy, with and without preserving the splenic vessels (i.e., the Kimura and Warshaw techniques, respectively).

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Medicine

Robotic D3 Partial Duodenal Resection with Primary Side-to-Side Anastomosis
Roberto Maria Montorsi 1,2,3, Sofia Xenaki 1,2,4, Sebastiaan Festen 5, Paul Fockens 2,6, Barbara A. J. Bastiaansen 2,6, Freek Daams 2,7, Olivier R. Busch 1,2, M. G. Besselink 1,2,
1Amsterdam UMC, Department of Surgery, University of Amsterdam, 2Cancer Center Amsterdam, 3Department of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, 4Department of General Surgery, University Hospital of Heraklion Crete, 5Department of Surgery, OLVG, 6Amsterdam UMC, Department of Gastroenterology, University of Amsterdam, 7Amsterdam UMC, Department of Surgery, Vrije Universiteit

This protocol presents a case of a robotic partial duodenal resection with primary side-to-side duodeno-jejunal reconstruction in a patient with a 5 cm duodenal stenosis. This is done at the third duodenal segment (D3) after an endoscopic mucosal resection (EMR) for a duodenal polyp.

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