Dissection of the Endolymphatic Sac from MiceKeiji Honda *1,2, Hyun Jae Lee *1, Andrew J. Griffith 1,3, Isabelle Roux 1
1Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 2Department of Otorhinolaryngology, Tokyo Medical and Dental University, 3Department of Otolaryngology, College of Medicine, University of Tennessee Health Science Center
This study describes how to dissect the endolymphatic sac from the inner ear of the mouse at different ages. The result of a similar dissection is shown in an Slc26a4-null mouse model of enlargement of the endolymphatic sac. A transgenic mouse with a fluorescent reporter expressed in the endolymphatic sac is presented as a model to readily visualize the endolymphatic sac, and educational tool.
