Quantitative MRI of Endothelial Permeability and (Dys)function in AtherosclerosisBegoña Lavin 1,2,3, Marcelo E. Andia 1,4,5, Prakash Saha 6, René M. Botnar 1,2,7,8, Alkystis Phinikaridou 1,2
1School of Biomedical Engineering and Imaging Sciences, King’s College London, 2BHF Centre of Excellence, Cardiovascular Division, King’s College London, 3Biochemistry and Molecular Biology Department, School of Chemistry, Complutense University, 4Radiology Department, School of Medicine, Pontificia Universidad Católica de Chile, 5ANID - Millennium Science Initiative Program - Millennium Nucleus for Cardiovascular Magnetic Resonance, 6Academic Department of Vascular Surgery, Cardiovascular Division, King’s College London, 7Wellcome Trust and EPSRC Medical Engineering Center, King’s College London, 8Escuela de Ingeniería, Universidad Católica de Chile
We have developed an accurate, non-invasive, and easy-to-use method to quantify endothelial permeability and dysfunction in the arteries using Magnetic Resonance Imaging (MRI), named qMETRIC. This technique enables assessing vascular damage and cardiovascular risk associated with atherosclerosis in preclinical models and humans.
