Universiti Malaya

3 ARTICLES PUBLISHED IN JoVE

Engineering

Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study

Musfirah Abd Aziz^1,2, Nur Azah Hamzaid^1,2, Nazirah Hasnan³

¹Biomechatronics and Neuroprosthetics Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, ²Center for Applied Biomechanics (CAB), Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, ³Department of Rehabilitation Medicine, Faculty of Medicine, Universiti Malaya

Arms contribution in Sit-To-Stand (SitTS) is determined by the legs' muscle condition. Several compensating strategies were discovered in efforts to achieve complete SitTS cycles. These findings triangulate the spinal cord injury (SCI) persons' biomechanical measures with their subjective feeling of load borne by both their limbs throughout the SitTS approaches.

Neuroscience

Locomotor Assessment of 6-Hydroxydopamine-induced Adult Zebrafish-based Parkinson's Disease Model

Naemah Md Hamzah¹, Siong Meng Lim¹, Yuganthini Vijayanathan^1,2, Fei Tieng Lim¹, Abu Bakar Abdul Majeed¹, Maw Pin Tan², Kalavathy Ramasamy¹

¹Collaborative Drug Discovery Research (CDDR) Group and Brain Degeneration and Therapeutics Group, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Puncak Alam, ²Department of Medicine, Faculty of Medicine, Universiti Malaya

The present protocol describes the intracerebroventricular (ICV) injection of adult zebrafish with neurotoxic 6-hydroxydopamine (6-OHDA) at the ventral diencephalon (Dn) and the assessment of the impairment and subsequent recovery of swimming behavior postlesion by using the open tank test, which is accompanied by analysis using a video tracking software.

Biology

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Mathanakumara Ealam Selvan^*1, Kai Shen Lim^*1, Chee How Teo², Yat-Yuen Lim¹

¹Institute of Biological Sciences, Faculty of Science, Universiti Malaya, ²Centre for Research in Biotechnology for Agriculture (CEBAR), Universiti Malaya

The protocol submitted here explains the complete in silico pipeline needed to predict and functionally characterize circRNAs from RNA-sequencing transcriptome data studying host-pathogen interactions.