Saveetha University

2 ARTICLES PUBLISHED IN JoVE

Bioengineering

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Sougata Ghosh^1,2,3, Tanay Bhagwat³, Rohini Kitture⁴, Sirikanjana Thongmee¹, Thomas J. Webster^3,5,6,7

¹Department of Physics, Faculty of Science, Kasetsart University, ²Department of Microbiology, School of Science, RK. University, ³Department of Chemical Engineering, Northeastern University, ⁴Defence Institute of Advanced Technology Campus, Navyukti Innovations Pvt. Ltd., ⁵Department of Biomedical Engineering, Hebei University of Technology, ⁶Department of Chemistry, Saveetha School of Engineering, Institute of Medical and Technical Science, Saveetha University, ⁷UFPI - Universidade Federal do Piauí

Novel nanocomposites of graphene nanoribbons and hydroxyapatite nanoparticles were prepared using solution-phase synthesis. These hybrids when employed in bioactive scaffolds can exhibit potential applications in tissue engineering and bone regeneration.

Medicine

Developing and Testing Methylated Nano-Structured Dipeptides that Inhibit Src Kinase Activity In Vitro for Anti-Cancer Applications

Alaa F. Nahhas¹, Alrayan F. Nahhas², Thomas J. Webster^3,4,5

¹Biochemistry Department, College of Science, King Abdulaziz University, ²Independent Scholar, ³School of Health Sciences and Biomedical Engineering, Hebei University of Technology, ⁴School of Engineering, Saveetha University, ⁵Programa de Pós-graduação em Ciência e Engenharia dos Materiais, UFPI

Presented here is a protocol for designing and testing dipeptides that can inhibit Src kinase enzyme activity using acellular and cellular assays for anti-cancer applications. The peptides formulated here (W-R_CH3, W_CH3-R_CH3, and W-R_(CH3)2) inhibited Src kinase with IC₅₀ values of 510 nM, 916 nM, and 1 µM, respectively.