Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue CollectionSafwan Alomari 1, Jayanidhi Kedda 1, Adarsha P. Malla 2,3, Victor Pacis 1, Pavlos Anastasiadis 2,3, Su Xu 4, Emylee McFarland 2,3, Lilia Sukhon 1, Bruno Gallo 5, Jordina Rincon-Torroella 1, Netanel Ben-Shalom 1, Heather M. Ames 3,6, Henry Brem 1,7, Graeme F. Woodworth 2,3, Betty Tyler 1
1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Neurosurgery, University of Maryland School of Medicine, 3Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, 4Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 5Pontifical Catholic University of Parana, 6Department of Pathology, University of Maryland School of Medicine, 7Departments of Ophthalmology, Oncology and Biomedical Engineering, Johns Hopkins University School of Medicine
The present protocol describes a standardized resection of brain tumors in rodents through a minimally invasive approach with an integrated tissue preservation system. This technique has implications for accurately mirroring the standard of care in rodent and other animal models.
