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CNR Institute of Clinical Physiology

3 ARTICLES PUBLISHED IN JoVE

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Medicine

Ultrasound-based Pulse Wave Velocity Evaluation in Mice
Nicole Di Lascio 1,2, Claudia Kusmic 2, Francesco Stea 2,3, Francesco Faita 2
1Institute of Life Science, Scuola Superiore Sant'Anna, 2Institute of Clinical Physiology, National Research Council, 3Department of Clinical and Experimental Medicine, University of Pisa

Arterial stiffness represents a key factor in cardiovascular disease and pulse wave velocity (PWV) can be considered as a surrogate index for arterial stiffness. This protocol describes an image processing algorithm for calculating PWV in mice based on ultrasound image processing that is applicable at different arterial sites.

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Cancer Research

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
Marianna Vitiello 1,2, Claudia Kusmic 1, Francesco Faita 1, Laura Poliseno 1,2
1Institute of Clinical Physiology, National Research Council (IFC-CNR), 2Oncogenomics Unit, Core Research Laboratory, ISPRO

Melanoma is a very aggressive disease that quickly spreads to other organs. This protocol describes the application of ultra-high-frequency ultrasound imaging, coupled with 3D rendering, to monitor the volume of the inguinal lymph nodes in the Braf/Pten mouse model of metastatic melanoma.

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Medicine

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Daniele Panetta 1, Maria Angela Guzzardi 1, Federica La Rosa 1, Federico Granziera 1,2, Domiziana Terlizzi 3, Claudia Kusmic 1, Patricia Iozzo 1
1CNR Institute of Clinical Physiology, 2Sant’Anna School of Advanced Studies, 3Fondazione Regione Toscana/CNR “G. Monasterio”

Here, we present an experimental imaging protocol for the quantification of cardiac function and morphology using high-resolution positron emission tomography/computed tomography for small animals. Both mice and rats are considered, discussing the different requirements of computed tomography contrast agents for the two species.

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