Drug Treatment by Central Venous Catheter in a Mouse Model of Angiotensin II Induced Abdominal Aortic Aneurysm and Monitoring by 3D UltrasoundNahla Ibrahim 1, Johannes Klopf 1, Sonja Bleichert 1, Marc A. Bailey 2,3, Albert Busch 4, Alexander Stiglbauer-Tscholakoff 5, Wolf Eilenberg 1, Christoph Neumayer 1, Christine Brostjan 1
1Division of Vascular Surgery, Department of General Surgery, Medical University of Vienna and Vienna General Hospital, 2Leeds Institute for Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, 3Leeds Vascular Institute, Leeds General Infirmary, 4Department for Visceral, Thoracic and Vascular Surgery, Technical University of Dresden and University Hospital Carl-Gustav Carus, 5Division of Cardiovascular and Interventional Radiology, Division of Molecular and Gender Imaging, Department of Biomedical Imaging and Image Guided Therapy, Medical University of Vienna and Vienna General Hospital
This protocol describes the consecutive implantation of an osmotic pump to induce abdominal aortic aneurysm by angiotensin II release in apolipoprotein E (ApoE) deficient mice and of a vascular access port with a jugular vein catheter for repeated drug treatment. Monitoring of aneurysm development by 3D ultrasound is effectively conducted despite dorsal implants.
