Surgery and Behavioral Testing in the Tibial Neuroma Transposition Model in RatsElisabeth Maria Brakkee 1, Erick DeVinney 2, Niels Eijkelkamp 3, J. Henk Coert 1
1Department of Plastic and Reconstructive Surgery, University Medical Center Utrecht, Utrecht University, 2Axogen, 3Center for Translational Immunology, University Medical Center Utrecht, Utrecht University
This protocol describes the tibial neuroma transposition model, which entails a lesion of the tibial nerve with subsequent transposition of the proximal nerve end toward a subcutaneous pretibial or lateral position. Behavioral testing of neuroma pain and plantar hyperalgesia is quantified using Von Frey monofilaments.
