An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture ModelIsadora da Silva Zanzarini 1, Gustavo Barbosa 1, Larissa de Oliveira Prado 1, Ingrid Fatima Zattoni 1, Gustavo Da Paz 1, Ademir Luiz do Prado 2,3, Waldemar Volanski 2, Marcos Dinís Lavarda 3, Fabiane Gomes de Moraes Rego 2, Geraldo Picheth 2, Vivian Rotuno Moure 1, Glaucio Valdameri 1
1Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, 2Graduate Program in Pharmaceutical Sciences, Federal University of Parana, 3Federal Institute of Parana
Here, we describe a novel, simple, and low-cost device to successfully perform in vitro photodynamic therapy (PDT) assays using two-dimensional HeLa cell culture and verteporfin as a photosensitizer.
