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the First Affiliated Hospital, Jinan University

4 ARTICLES PUBLISHED IN JoVE

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Medicine

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Xiaohui Li *1,2, Weijiang Tan *1,3, Xiang Li *1, Shuang Zheng *1, Xiaoshen Zhang 2, Honghua Chen 1, Zhanhong Pan 1, Caiyi Zhu 1, Feng Hua Yang 1
1Guangdong Laboratory Animals Monitoring Institute, 2Department of Cardiovascular Surgery, the First Affiliated Hospital, Jinan University, 3College of Veterinary Medicine, South China Agricultural University

The present protocol describes a step-by-step procedure to establish a minipig model of heart failure with preserved ejection fraction using descending aortic constriction. The methods for evaluating cardiac morphology, histology, and function of this disease model are also presented.

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Medicine

Establishment and Evaluation of a Porcine Vein Graft Disease Model
Xiaohui Li *1, Jinlin Hu *1, Weijiang Tan *2, Zhaoming Lin *1, Caiyi Zhu 2, Chengfeng Huang 1, Jiawen Huang 3, Yintian Liu 1, Qiuying Liao 1, Hua Lu 1, Xiaoshen Zhang 1
1Department of Cardiovascular Surgery, the First Affiliated Hospital of Jinan University, 2Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, 3The First Affiliated Hospital of Jinan University

In this protocol, novel pig vein bypass grafting was performed through a small incision in the left chest wall without cardiopulmonary bypass. A postoperative pathology study was done, which showed intimal thickening.

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Medicine

Laparoscopic Posterior Radical Antegrade Modular Pancreatosplenectomy for Distal Pancreatic Carcinoma
Junjie Liang *1, Quan Jiang *1, Leyang Xiang *1, Yuchuan Jiang 1,2, Jiexing Li 1, Zhilong Liu 1, Qiang Li 1, Mingrong Cao 1, Youzhu Hu 1,3, Jian Sun 1
1Department of Hepatobiliary Surgery, The First Affiliated Hospital, Jinan University, 2Department of Gastroenterology, The Second Affiliated Hospital, Nanchang University, 3Department of General Surgery, The Affiliated Shunde Hospital, Jinan University

Laparoscopic radical antegrade modular pancreatosplenectomy (L-RAMPS) is currently considered technically safe and feasible. However, due to technical challenges and a lack of supporting evidence for widespread clinical applications, only a limited number of institutions are currently conducting L-RAMPS. This article aims to provide detailed techniques for laparoscopic posterior radical antegrade modular pancreatosplenectomy.

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Medicine

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Qiang Li *1, Xiaolan Wang *1,2, Deju Li *1, Yulong Liu *3, Kangshou Liu 1, Junjie Liang 1, Jian Sun 1, Quan Jiang 1, Jiexing Li 1, Zhilong Liu 1, Jian Gong 4, Leyang Xiang 1, Zhidong Jia 1, Zhiwei Chen 1, Mingrong Cao 1, Yuchuan Jiang 1,5
1Department of Hepatobiliary Surgery, The First Affiliated Hospital, Jinan University, 2Dongpu Branch, The First Affiliated Hospital, Jinan University, 3Department of Vascular Intervention, The First Affiliated Hospital, Jinan University, 4Department of Nuclear Medicine, The First Affiliated Hospital, Jinan University, 5Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University

This study illustrates the methodological potential of combining Yttrium-90 Trans-Arterial Radioembolization (Y-90 TARE) with an anti-PD-1 monoclonal antibody as an effective neoadjuvant strategy leading to hepatectomy in hepatocellular carcinoma (HCC) patients with a high initial recurrence risk. It emphasizes the safety, feasibility, and step-by-step procedural guidance of this approach.

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