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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

DOI :

10.3791/63526-v

February 18th, 2022

February 18th, 2022

1,186 Views

1Guangdong Laboratory Animals Monitoring Institute, 2Department of Cardiovascular Surgery, the First Affiliated Hospital, Jinan University, 3College of Veterinary Medicine, South China Agricultural University

The present protocol describes a step-by-step procedure to establish a minipig model of heart failure with preserved ejection fraction using descending aortic constriction. The methods for evaluating cardiac morphology, histology, and function of this disease model are also presented.

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