Douglas R. Seals

Decline in insulin action with age in endurance-trained humans.

The influence of aging on the human sympathetic nervous system and brain norepinephrine turnover.

Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men.

Is autonomic support of arterial blood pressure related to habitual exercise status in healthy men?

Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress.

Changes in maximal aerobic capacity with age in endurance-trained women: 7-yr follow-up.

Arterial intima-media thickness: site-specific associations with HRT and habitual exercise.

Declines in physiological functional capacity with age: a longitudinal study in peak swimming performance.

Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice.

Greater rate of decline in maximal aerobic capacity with age in endurance-trained than in sedentary men.

Use of acetylene breathing to determine cardiac output in young and older adults.

Basal leg blood flow in healthy women is related to age and hormone replacement therapy status.

Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women.

Baroreflex buffering is reduced with age in healthy men.

Habitual exercise and the age-associated decline in large artery compliance.

Baroreflex buffering in sedentary and endurance exercise-trained healthy men.

Invited Review: Dynamic exercise performance in Masters athletes: insight into the effects of primary human aging on physiological functional capacity.

Adiposity contributes to differences in left ventricular structure and diastolic function with age in healthy men.

Oxidative stress does not modulate metabolic rate or skeletal muscle sympathetic activity with primary aging in adult humans.

Left ventricular structure and diastolic function with human ageing. Relation to habitual exercise and arterial stiffness.

Chronic sympathetic activation: consequence and cause of age-associated obesity?

Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing.

Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men.

Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men.

Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension.

Increased abdominal-to-peripheral fat distribution contributes to altered autonomic-circulatory control with human aging.

High energy flux mediates the tonically augmented beta-adrenergic support of resting metabolic rate in habitually exercising older adults.

Role of sympathetic neural activation in age- and habitual exercise-related differences in the thermic effect of food.

Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging.

Ascorbic acid does not affect the age-associated reduction in maximal cardiac output and oxygen consumption in healthy adults.

Stiffening our resolve against adult weight gain.

Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men.

Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men.

Ascorbic acid selectively improves large elastic artery compliance in postmenopausal women.

Aortic input impedance increases with age in healthy men and women.

Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults.

Thermogenic responsiveness to nonspecific beta-adrenergic stimulation is not related to genetic variation in codon 16 of the beta2-adrenergic receptor.

Thermogenic responsiveness to beta-adrenergic stimulation is augmented in exercising versus sedentary adults: role of oxidative stress.

Cardiac vagal modulation of heart rate during prolonged submaximal exercise in animals with healed myocardial infarctions: effects of training.

Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing.

Modulatory influences on ageing of the vasculature in healthy humans.

Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression.

Oxidative stress explains differences in large elastic artery compliance between sedentary and habitually exercising postmenopausal women.

Habitual aerobic exercise is associated with smaller femoral artery intima-media thickness with age in healthy men and women.

Oxidative stress contributes to chronic leg vasoconstriction in estrogen-deficient postmenopausal women.

A transdisciplinary model integrating genetic, physiological, and psychological correlates of voluntary exercise.

Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress.

Commentary on Viewpoint "Human experimentation: no accurate, quantitative data?".

Thermic effect of food and beta-adrenergic thermogenic responsiveness in habitually exercising and sedentary healthy adult humans.

Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB.

Increased thermogenic responsiveness to intravenous beta-adrenergic stimulation in habitually exercising humans is not related to skeletal muscle beta2-adrenergic receptor density.

Endurance exercise performance in Masters athletes: age-associated changes and underlying physiological mechanisms.

High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men.

Decreased maximal heart rate with aging is related to reduced {beta}-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate.

Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults.

Habitual exercise and arterial aging.

Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans.

Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans.

Modulation of vascular endothelial function by low-density lipoprotein cholesterol with aging: influence of habitual exercise.

2013 APS Edward F. Adolph Distinguished Lecture The Remarkable Anti-Aging Effects of Aerobic Exercise on Systemic Arteries.

B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging.

Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans.

Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase.

Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase.

Vascular endothelial estrogen receptor alpha is modulated by estrogen status and related to endothelial function and endothelial nitric oxide synthase in healthy women.

Protein expression in vascular endothelial cells obtained from human peripheral arteries and veins.

Habitual exercise and vascular ageing.

Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure.

Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults.

Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity.

Role of NFkappaB in age-related vascular endothelial dysfunction in humans.

Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults.

Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: reversal by aerobic exercise.

Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK.

25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults.

The importance of population-wide sodium reduction as a means to prevent cardiovascular disease and stroke: a call to action from the American Heart Association.

Aging and vascular endothelial function in humans.

Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging.

Salicylate treatment improves age-associated vascular endothelial dysfunction: potential role of nuclear factor kappaB and forkhead Box O phosphorylation.

Exercise protects against myocardial ischemia-reperfusion injury via stimulation of β(3)-adrenergic receptors and increased nitric oxide signaling: role of nitrite and nitrosothiols.

Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise.

Aerobic exercise reverses arterial inflammation with aging in mice.

SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans.

Plasma norepinephrine is an independent predictor of vascular endothelial function with aging in healthy women.

Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress.

Replicative aging induces endothelial to mesenchymal transition in human aortic endothelial cells: potential role of inflammation.

MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation.

Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice.

Vascular Endothelial Function Is Not Related to Serum Uric Acid in Healthy Adults.

Vascular health in the ageing athlete.

Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism.

Translational evidence that impaired autophagy contributes to arterial ageing.

Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products.

Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study.

Hysterectomy is associated with large artery stiffening in estrogen-deficient postmenopausal women.

Vascular smooth muscle responsiveness to nitric oxide is reduced in healthy adults with increased adiposity.

Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging.

Fenofibrate improves vascular endothelial function by reducing oxidative stress while increasing endothelial nitric oxide synthase in healthy normolipidemic older adults.

Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure.

Curcumin ameliorates arterial dysfunction and oxidative stress with aging.

The dependence of FMD% on baseline diameter: a problem solved by allometric scaling - no problem in this case.

The autophagy enhancer spermidine reverses arterial aging.

Aortic Pulse Wave Velocity and Reflecting Distance Estimation from Peripheral Waveforms in Humans: Detection of Age- and Exercise Training-Related Differences.

Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice.

Translational physiology: from molecules to public health.

Response to effect of fenofibrate on vascular endothelial function: statistical appraisal and its validity.

Activation of the unfolded protein response in vascular endothelial cells of nondiabetic obese adults.

Dietary sodium restriction and association with urinary marinobufagenin, blood pressure, and aortic stiffness.

Aging compounds western diet-associated large artery endothelial dysfunction in mice: prevention by voluntary aerobic exercise.

Essential role of estrogen for improvements in vascular endothelial function with endurance exercise in postmenopausal women.

Battery of behavioral tests in mice that models age-associated changes in human motor function.

Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults.

Superoxide signaling in perivascular adipose tissue promotes age-related artery stiffness.

Inorganic nitrite supplementation for healthy arterial aging.