Ronald T. Hay

SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression.

In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy.

Ribosomal proteins are targets for the NEDD8 pathway.

NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts.

Quantitative analysis of multi-protein interactions using FRET: application to the SUMO pathway.

Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity.

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.

Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo.

FRET-based in vitro assays for the analysis of SUMO protease activities.

Characterization of SENP7, a SUMO-2/3-specific isopeptidase.

System-wide changes to SUMO modifications in response to heat shock.

An additional role for SUMO in ubiquitin-mediated proteolysis.

Detection of protein SUMOylation in vivo.

Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation.

High-stringency tandem affinity purification of proteins conjugated to ubiquitin-like moieties.

Post-translational modification by SUMO.

SUMOylation of the GTPase Rac1 is required for optimal cell migration.

Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies.

Functional interactions between ubiquitin E2 enzymes and TRIM proteins.

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies.

Purification and identification of endogenous polySUMO conjugates.

Comparative proteomic analysis identifies a role for SUMO in protein quality control.

Absolute SILAC-compatible expression strain allows Sumo-2 copy number determination in clinical samples.

Mechanism of ubiquitylation by dimeric RING ligase RNF4.

Stable-isotope labeling with amino acids in nematodes.

Detection and quantitation of SUMO chains by mass spectrometry.

SUMOylation of HNF4α regulates protein stability and hepatocyte function.

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage.

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis.

Reanalysis of phosphoproteomics data uncovers ADP-ribosylation sites.

The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.

Decoding the SUMO signal.

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini.

Iso-seco-tanapartholides: Isolation, Synthesis and Biological Evaluation.

A role for paralog-specific sumoylation in histone deacetylase 1 stability.

BC-box protein domain-related mechanism for VHL protein degradation.

PML isoforms in response to arsenic: high resolution analysis of PML body structure and degradation characteristics.

SUMO chain-induced dimerization activates RNF4.

E3 Ubiquitin Ligase HOIP Attenuates Apoptotic Cell Death Induced by Cisplatin.

Proteome-Wide Identification of SUMO2 Modification Sites.

Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity.