Bon-Kyoung Koo

Controlled gene expression in primary Lgr5 organoid cultures.

Mind bomb-2 is an E3 ligase for Notch ligand.

Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.

Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2.

Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish.

Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.

An obligatory role of mind bomb-1 in notch signaling of mammalian development.

Crif1 is a novel transcriptional coactivator of STAT3.

A crucial role of WW45 in developing epithelial tissues in the mouse.

Mind bomb 1-expressing intermediate progenitors generate notch signaling to maintain radial glial cells.

Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches.

Defective Notch activation in microenvironment leads to myeloproliferative disease.

Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development.

Notch signaling promotes the generation of EphrinB1-positive intestinal epithelial cells.

Essential role of CR6-interacting factor 1 (Crif1) in E74-like factor 3 (ELF3)-mediated intestinal development.

Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.

The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling.

A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.

Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer.

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.

Generation of BAC transgenic epithelial organoids.

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.

Retroviral gene expression control in primary organoid cultures.

Stem Cells Marked by the R-Spondin Receptor LGR5.

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.

Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.

Modeling mouse and human development using organoid cultures.

Adult stem cell lineage tracing and deep tissue imaging.

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.

Clonal Evolution of Stem Cells in the Gastrointestinal Tract.

Organoids: A new in vitro model system for biomedical science and disease modelling and promising source for cell-based transplantation.

Simultaneous paralogue knockout using a CRISPR-concatemer in mouse small intestinal organoids.

Adult gastric stem cells and their niches.

One-step generation of conditional and reversible gene knockouts.

Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium.

Stem Cells in Repair of Gastrointestinal Epithelia.