Friedrich Koch-Nolte

Complex regulation of the human gene for the Z-DNA binding protein DLM-1.

Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide.

The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse.

Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2).

Independent integration of rodent identifier (ID) elements into orthologous sites of some RT6 alleles of Rattus norvegicus and Rattus rattus.

Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat.

Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice.

Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor.

Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine.

Analysis of subcellular calcium signals in T-lymphocytes.

Substrate binding and catalysis of ecto-ADP-ribosyltransferase 2.2 from rat.

NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor.

Triggering of T-cell apoptosis by toxin-related ecto-ADP-ribosyltransferase ART2.

T-cell survival regulator LKLF is not involved in inappropriate apoptosis of diabetes-prone BBDP rat T cells.

Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling.

T cells of different developmental stages differ in sensitivity to apoptosis induced by extracellular NAD.

FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.

Activity and specificity of toxin-related mouse T cell ecto-ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts.

A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains.

CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.

Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate.

Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization.

A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens.

Characterization of multiple alleles of the T-cell differentiation marker ART2 (RT6) in inbred and wild rats.

In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs).

The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system.

"Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells.

Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation.

FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of human ARH3, the first eukaryotic protein-ADP-ribosylhydrolase.

Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.

Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.

Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes.

ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells.

ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains.

The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation.

FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.

Emerging functions of extracellular pyridine nucleotides.

Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo.

NAD+ released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo.

CD83 modulates B cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells.

ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site.

Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages.

Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix.

Structure of mouse ADP-ribosylhydrolase 3 (mARH3).

Extracellular NAD and ATP: Partners in immune cell modulation.

Monitoring the expression of purinoceptors and nucleotide-metabolizing ecto-enzymes with antibodies directed against proteins in native conformation.

Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases.

High sensitivity of intestinal CD8+ T cells to nucleotides indicates P2X7 as a regulator for intestinal T cell responses.

Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function.

ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells.

Emerging roles of NAD+ and its metabolites in cell signaling.

NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells.

Characterisation of the R276A gain-of-function mutation in the ectodomain of murine P2X7.

Activation of the P2X7 ion channel by soluble and covalently bound ligands.

Basal and inducible expression of the thiol-sensitive ART2.1 ecto-ADP-ribosyltransferase in myeloid and lymphoid leukocytes.

Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1.

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.

Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells.

Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E).

A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes.

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

Quantitative magnetic resonance imaging of enzyme activity on the cell surface: in vitro and in vivo monitoring of ADP-ribosyltransferase 2 on T cells.

ADP-ribosylation of arginine.

Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium.

Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.

Compartmentation of NAD+-dependent signalling.

Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.

Progress in the function and regulation of ADP-Ribosylation.

CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia.

Transgenic overexpression of toxin-related ecto-ADP-ribosyltransferase ART2.2 sensitizes T cells but not B cells to NAD-induced cell death.

Strategies for the identification of arginine ADP-ribosylation sites.

Monoclonal antibodies for the identification and purification of vNAR domains and IgNAR immunoglobulins from the horn shark Heterodontus francisci.

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail.

Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation.

Extracellular NAD(+): a danger signal hindering regulatory T cells.

Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.

CD8-β ADP-ribosylation affects CD8(+) T-cell function.

The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs.

Physiology of ADP-ribosylation.

CD38 controls the innate immune response against Listeria monocytogenes.

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.

Technical Advance: a new cell preparation strategy that greatly improves the yield of vital and functional Tregs and NKT cells.

Mucolipidosis II-related mutations inhibit the exit from the endoplasmic reticulum and proteolytic cleavage of GlcNAc-1-phosphotransferase precursor protein (GNPTAB).

Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.

Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence.

In vivo near-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies.

ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells.

ARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responses.

Nanobodies as modulators of inflammation: potential applications for acute brain injury.

Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT.

The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation.

Tuning IL-2 signaling by ADP-ribosylation of CD25.