Christian Siebold

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.

Multiple sclerosis: MHC associations and therapeutic implications.

High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule.

Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion.

MHC class II proteins and disease: a structural perspective.

Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.

Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function.

Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism.

Structure and functional analysis of the IGF-II/IGF2R interaction.

Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73.

Receptor protein tyrosine phosphatase micro: measuring where to stick.

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors.

Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling.

Interactions between Hedgehog proteins and their binding partners come into view.

Structural basis of semaphorin-plexin signalling.

Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis.

Automation of large scale transient protein expression in mammalian cells.

Recording information on protein complexes in an information management system.

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1.

A dual binding mode for RhoGTPases in plexin signalling.

Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling.

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.

Structural insights into semaphorins and their receptors.

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.

Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.

Structural insights into proteoglycan-shaped Hedgehog signaling.

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein.

Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function.

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.

Initiation of T cell signaling by CD45 segregation at 'close contacts'.

Structural basis for integration of GluD receptors within synaptic organizer complexes.

Structural basis of Smoothened regulation by its extracellular domains.

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling.

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.