Haruhiko Sugimura

p53 accumulation in colorectal cancer with hepatic metastasis.

Genetic alterations of mixed hyperplastic adenomatous polyps in the colon and rectum.

Association of Ile462Val (Exon 7) polymorphism of cytochrome P450 IA1 with lung cancer in the Asian population: further evidence from a case-control study in Okinawa.

Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer.

Activation of Rac1 by a Crk SH3-binding protein, DOCK180.

Antitumor effect of a neutralizing antibody to vascular endothelial growth factor on liver metastasis of endocrine neoplasm.

Mutational analyses of multiple target genes in histologically heterogeneous gastric cancer with microsatellite instability.

Mxi1 mutations in human neurofibrosarcomas.

hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.

Isolation and localization of type IIb Na/Pi cotransporter in the developing rat lung.

Intratumor heterogeneity of centromere numerical abnormality in multiple primary gastric cancers: application of fluorescence in situ hybridization with intermittent microwave irradiation on paraffin-embedded tissue.

Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1.

Genomic structure of the human beta-PIX gene and its alteration in gastric cancer.

Effect of genotypic differences in interleukin-1 beta on gastric acid secretion in Japanese patients infected with Helicobacter pylori.

Bilateral cavernous sinus actinomycosis resulting in painful ophthalmoplegia. Case report.

Total gastrectomy is not always necessary for advanced gastric cancer of the cardia.

Diverticulitis causing a high serum level of carbohydrate antigen 19-9: report of a case.

Gastrojejunocolic fistula after gastrectomy with Billroth II reconstruction: report of a case.

Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan.

Expression profile of EFNB1, EFNB2, two ligands of EPHB2 in human gastric cancer.

Detection of chromosome changes in pathology archives: an application of microwave-assisted fluorescence in situ hybridization to human carcinogenesis studies.

Negative regulation of EphA2 receptor by Cbl.

Role of Wnt pathway in medulloblastoma oncogenesis.

Centromere numerical abnormality in the papillary, papillotubular type of early gastric cancer, a further characterization of a subset of gastric cancer.

Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts.

Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion.

Ile-Leu substitution (I415L) in germline E-cadherin gene (CDH1) in Japanese familial gastric cancer.

Evidence for the critical role of interleukin-12 but not interferon-gamma in the pathogenesis of experimental colitis in mice.

[Basic studies on mutation analysis of K-ras codon 12 by use of three-dimensional microarray system].

Promoter hypermethylation in cancer silences LDHB, eliminating lactate dehydrogenase isoenzymes 1-4.

Nonrandom chromosomal numerical abnormality predicting prognosis of gastric cancer: a retrospective study of 51 cases using pathology archives.

EphA2 up-regulation induced by deoxycholic acid in human colon carcinoma cells, an involvement of extracellular signal-regulated kinase and p53-independence.

[Molecular biology of colorectal cancer: The cell cycle and its regulation].

Multiple (multicentric and multifocal) cancers in the ipsilateral breast with different histologies: profiles of chromosomal numerical abnormality.

A novel secretory factor, Neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus.

Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer.

Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2.

Polymorphism of interleukin-1beta affects the eradication rates of Helicobacter pylori by triple therapy.

Three-dimensional microarray compared with PCR-single-strand conformation polymorphism analysis/DNA sequencing for mutation analysis of K-ras codons 12 and 13.

A novel splice-site variant of the base excision repair gene MYH is associated with production of an aberrant mRNA transcript encoding a truncated MYH protein not localized in the nucleus.

Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening.

Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity.

Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer.

[A case of gastric GIST treated preoperatively by imatinib mesylate].

Amplicons on human chromosome 11q are located in the early/late-switch regions of replication timing.

[Two cases of postoperative recurrence of gastric GIST treated by imatinib].

Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.

EPHA2/EFNA1 expression in human gastric cancer.

Pilot study of arbitrarily primed PCR-single stranded DNA conformation polymorphism analysis for screening genetic polymorphisms related to specific phenotypes.

Downregulation of EphA7 by hypermethylation in colorectal cancer.

Effect of splice-site polymorphisms of the TMPRSS4, NPHP4 and ORCTL4 genes on their mRNA expression.

Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner.

Immunohistochemical and genetic features of gastric and metastatic liver gastrointestinal stromal tumors: sequential analyses.

Chromosomal numerical abnormality profiles of gastrointestinal stromal tumors.

Chromosomal numerical abnormalities in early stage lung adenocarcinoma.

Overexpression of heat shock protein 27 is associated with good prognosis in the patient with oral squamous cell carcinoma.

Repeated fluorescence in situ hybridization by a microwave-enhanced protocol.

[Manifestation of liver metastasis 13 years after gastrectomy for gastric GIST].

Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan.

p16INK4A in oral squamous cell carcinomas--a correlation with biological behaviors: immunohistochemical and FISH analysis.

Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer.

Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese.

Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epidermal growth factor receptor gene mutation.

Identification and characterization of a novel germ line p53 mutation in familial gastric cancer in the Japanese population.

Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects.

Association between CDH1 haplotypes and gastric cancer risk in a Japanese population.

Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors.

p53-dependent change in replication timing of the human genome.

CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.

Colonic fistula associated with severe acute pancreatitis: report of two cases.

EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas.

Association between genetic polymorphisms of the base excision repair gene MUTYH and increased colorectal cancer risk in a Japanese population.

Congenital anaplastic astrocytoma differentiated into pilocytic astrocytoma: an autopsy case.

Fluorescence-labeled methylation-sensitive amplified fragment length polymorphism (FL-MS-AFLP) analysis for quantitative determination of DNA methylation and demethylation status.

[Familial aggregation of gastric cancer].

MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese.

Inverse relationship between the length of the EGFR CA repeat polymorphism in lung carcinoma and protein expression of EGFR in the carcinoma.

Malignant pheochromocytoma in a young adult forming the structure simulating Homer Wright rosette: differentiation from neuroblastoma on repeating fluorescence in situ hybridization.

OGG1, MYH and MTH1 gene variants identified in gastric cancer patients exhibiting both 8-hydroxy-2'-deoxyguanosine accumulation and low inflammatory cell infiltration in their gastric mucosa.

Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan.

Copy number estimation algorithms and fluorescence in situ hybridization to describe copy number alterations in human tumors.

Identification and characterization of a novel germline p53 mutation in a patient with glioblastoma and colon cancer.

Altered expression of the human base excision repair gene NTH1 in gastric cancer.

Fecal cyclooxygenase 2 plus matrix metalloproteinase 7 mRNA assays as a marker for colorectal cancer screening.

MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.

Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients.

Relationship between low-dose aspirin-induced gastric mucosal injury and intragastric pH in healthy volunteers.

Esophageal mucosal injury with low-dose aspirin and its prevention by rabeprazole.

Imaging mass spectrometry of gastric carcinoma in formalin-fixed paraffin-embedded tissue microarray.

Secreted form of EphA7 in lung cancer.

Rare form of extraovarian peritoneal serous papillary carcinoma with solitary tumor in the abdominal wall: a case report and literature review.

Association between neurexin 1 (NRXN1) polymorphisms and the smoking behavior of elderly Japanese.

Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma.

Fluorescence in situ hybridization analysis with a tissue microarray: 'FISH and chips' analysis of pathology archives.

Preventive effects of lansoprazole and famotidine on gastric mucosal injury induced by low-dose aspirin in Helicobacter pylori-negative healthy volunteers.

SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals.

Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese.

Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer.

Identification of 5 novel germline APC mutations and characterization of clinical phenotypes in Japanese patients with classical and attenuated familial adenomatous polyposis.

Three novel NEIL1 promoter polymorphisms in gastric cancer patients.

EPH-EPHRIN in human gastrointestinal cancers.

Microarray analysis identifies versican and CD9 as potent prognostic markers in gastric gastrointestinal stromal tumors.

Aberrant expression and mutation-inducing activity of AID in human lung cancer.

Lymphatic vessel invasion is a significant prognostic indicator in stage IA lung adenocarcinoma.

Genetic susceptibility to lung cancer.

Germline alterations in the CDH1 gene in familial gastric cancer in the Japanese population.

Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer.

The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer.

Detection of kinase amplifications in gastric cancer archives using fluorescence in situ hybridization.

EML4-ALK fusion transcripts in immunohistochemically ALK-positive non-small cell lung carcinomas.

Chromogenic in situ hybridization (CISH) to detect HER2 gene amplification in breast and gastric cancer: comparison with immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH).

Hepatocellular adenoma associated with familial adenomatous polyposis coli.

Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis.

Internal frontier: the pathophysiology of the small intestine.

[Familial gastric cancer - an update of Japanese cases].

Editorial: an obsession with subtyping gastric cancer.

Visualization of phosphatidylcholine (16:0/16:0) in type II alveolar epithelial cells in the human lung using imaging mass spectrometry.

D2-40-positive lymphatic vessel invasion is not a poor prognostic factor in stage I lung adenocarcinoma.

Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene.

Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4.

CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma.

Breakages at YWHAE, FAM22A, and FAM22B loci in uterine angiosarcoma: a case report with immunohistochemical and genetic analysis.

SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers.

Establishment and characterization of a mutagenized cell line exhibiting the 'cell-in-cell' phenotype at a high frequency.

TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer.

A novel somatic FGFR3 mutation in primary lung cancer.

A rare Japanese case with a NUT midline carcinoma in the nasal cavity: a case report with immunohistochemical and genetic analyses.

YB-1 promotes transcription of cyclin D1 in human non-small-cell lung cancers.

Impaired 8-hydroxyguanine repair activity of MUTYH variant p.Arg109Trp found in a Japanese patient with early-onset colorectal cancer.

RSPO fusion transcripts in colorectal cancer in Japanese population.

Radiation-induced breast angiosarcoma with a confirmative feature of c-MYC amplification.

PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer.

Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer.

Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts.

NSD3-NUT-expressing midline carcinoma of the lung: first characterization of primary cancer tissue.

CLCA2 as a novel immunohistochemical marker for differential diagnosis of squamous cell carcinoma from adenocarcinoma of the lung.

CD44-SLC1A2 fusion transcripts in primary colorectal cancer.

Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring the NSD3-NUT Fusion Gene: A Case Report and Literature Review.

SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patients with colorectal cancer.

Maspin-related Orchestration of Aggressiveness of Gastric Cancer.

BSND and ATP6V1G3: Novel Immunohistochemical Markers for Chromophobe Renal Cell Carcinoma.

CYP2A6 genetic polymorphism is associated with decreased susceptibility to squamous cell lung cancer in Japanese smokers.

NEIL1 p.Gln282Stop variant is predominantly localized in the cytoplasm and exhibits reduced activity in suppressing mutations.

Association between AKT1 Gene Polymorphism rs2498794 and Smoking-Related Traits with reference to Cancer Susceptibility.

Hereditary diffuse gastric cancer--An overview.

Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.

Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation.

Uterine Angiosarcoma: A Case Report and Literature Review.

The inner centromere-shugoshin network prevents chromosomal instability.

New Insights in Histogenetic Pathways of Gastric Cancer.

Clinicopathological and Survival Analysis of Japanese Patients with Resected Non-Small-Cell Lung Cancer Harboring NKX2-1, SETDB1, MET, HER2, SOX2, FGFR1, or PIK3CA Gene Amplification.

Functional Evaluation of Nine Missense-Type Variants of the Human DNA Glycosylase Enzyme MUTYH in the Japanese Population.

Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs.

Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer.

Clinical significance of PD-L1 and PD-L2 copy number gains in non-small-cell lung cancer.

A novel APC mosaicism in a patient with familial adenomatous polyposis.

Visualization of sphingolipids and phospholipids in the fundic gland mucosa of human stomach using imaging mass spectrometry.

Susceptibility to human cancer: From the perspective of a pathologist.

Reduced expression of the DNA glycosylase gene MUTYH is associated with an increased number of somatic mutations via a reduction in the DNA repair capacity in prostate adenocarcinoma.

Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese.

A novel prognostic marker of non-small cell lung cancer: chromosome 9 open reading frame 86 ().

CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis.

Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer.

High expression of Wls is associated with lymph node metastasis and advanced TNM stage in gastric carcinomas.

Successful crizotinib monotherapy in -mutant lung adenocarcinoma with acquired amplification after erlotinib therapy.

WDR62 overexpression is associated with a poor prognosis in patients with lung adenocarcinoma.

Rapid Radiologic Progression of Silicosis.

Distinct prognostic roles and heterogeneity of TTF1 copy number and TTF1 protein expression in non-small cell lung cancer.

BSND is a Novel Immunohistochemical Marker for Oncocytic Salivary Gland Tumors.

Characterization of V-set and immunoglobulin domain containing 1 exerting a tumor suppressor function in gastric, lung, and esophageal cancer cells.

Immunohistochemical expression analysis of leucine-rich PPR-motif-containing protein (LRPPRC), a candidate colorectal cancer biomarker identified by shotgun proteomics using iTRAQ.

Homeobox Transcription Factor NKX2-1 Promotes Transcription in Lung Adenocarcinomas.

Insertionally polymorphic sites of human endogenous retrovirus-K (HML-2) with long target site duplications.

Application of digital PCR with chip-in-a-tube format to analyze Adenomatous polyposis coli (APC) somatic mosaicism.

Mutation Spectrum Induced by 8-Bromoguanine, a Base Damaged by Reactive Brominating Species, in Human Cells.

Immunohistochemical features and staging of early gastric cancer.

Editorial Comment on Validation of the digital PCR system for use in tyrosine kinase inhibitor-resistant EGFR-mutant non-small-cell lung cancer.

frameshift mutation caused by DNA mismatch repair deficiency enhances cytotoxicity by trifluridine, an active antitumor agent of TAS-102, in colorectal cancer cells.

Heterogeneous MET gene copy number and EGFR mutation elicit discordant responses to crizotinib between primary and metastatic lesions in erlotinib-resistant lung adenocarcinoma.

Distinctive characteristics and prognostic significance of interstitial pneumonia with autoimmune features in patients with chronic fibrosing interstitial pneumonia.