Department of Molecular Biology and Biochemistry,
Sue and Bill Gross Stem Cell Center,
Institute for Immunology
Thomas E. Lane has not added Biography.
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Lack of nitric oxide synthase type 2 (NOS2) results in reduced neuronal apoptosis and mortality following mouse hepatitis virus infection of the central nervous system.
Journal of neurovirology Feb, 2002 | Pubmed ID: 11847593
IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2002 | Pubmed ID: 11907072
Mouse hepatitis virus infection of the central nervous system: chemokine-mediated regulation of host defense and disease.
Viral immunology , 2002 | Pubmed ID: 12081011
Functional expression of chemokine receptor CCR5 on CD4(+) T cells during virus-induced central nervous system disease.
Journal of virology Jan, 2003 | Pubmed ID: 12477824
CC chemokine ligand 3 (CCL3) regulates CD8(+)-T-cell effector function and migration following viral infection.
Journal of virology Apr, 2003 | Pubmed ID: 12634360
Adenovirus-mediated expression of CXCL10 in the central nervous system results in T-cell recruitment and limited neuropathology.
Journal of neurovirology Jun, 2003 | Pubmed ID: 12775415
Functional analysis of the CC chemokine receptor 5 (CCR5) on virus-specific CD8+ T cells following coronavirus infection of the central nervous system.
Virology Aug, 2003 | Pubmed ID: 12919745
Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection.
Journal of virology Sep, 2003 | Pubmed ID: 12941914
Measles virus infection induces chemokine synthesis by neurons.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2003 | Pubmed ID: 12960336
Reducing inflammation decreases secondary degeneration and functional deficit after spinal cord injury.
Experimental neurology Nov, 2003 | Pubmed ID: 14637115
CXC chemokine ligand 10 controls viral infection in the central nervous system: evidence for a role in innate immune response through recruitment and activation of natural killer cells.
Journal of virology Jan, 2004 | Pubmed ID: 14694090
Distinct roles for IP-10/CXCL10 in three animal models, Theiler's virus infection, EAE, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10.
Multiple sclerosis (Houndmills, Basingstoke, England) Feb, 2004 | Pubmed ID: 14760949
Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2004 | Pubmed ID: 15034013
Remyelination, axonal sparing, and locomotor recovery following transplantation of glial-committed progenitor cells into the MHV model of multiple sclerosis.
Experimental neurology Jun, 2004 | Pubmed ID: 15144852
Enhanced T cell proliferation in mice lacking the p85beta subunit of phosphoinositide 3-kinase.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2004 | Pubmed ID: 15153476
The CC chemokine ligand 3 regulates CD11c+CD11b+CD8alpha- dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell activation.
Virology Sep, 2004 | Pubmed ID: 15327893
Consequences of CXCL10 and IL-6 induction by the murine IFN-alpha1 transgene in ocular herpes simplex virus type 1 infection.
Immunologic research , 2004 | Pubmed ID: 15477660
Differential roles of CCL2 and CCR2 in host defense to coronavirus infection.
Virology Nov, 2004 | Pubmed ID: 15518805
Neutralization of chemokines RANTES and MIG increases virus antigen expression and spinal cord pathology during Theiler's virus infection.
International immunology May, 2005 | Pubmed ID: 15824069
Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion.
Science (New York, N.Y.) Jun, 2005 | Pubmed ID: 15933199
Transplantation of glial-committed progenitor cells into a viral model of multiple sclerosis induces remyelination in the absence of an attenuated inflammatory response.
Experimental neurology Feb, 2006 | Pubmed ID: 16297915
The chemokines CXCL9 and CXCL10 promote a protective immune response but do not contribute to cardiac inflammation following infection with Trypanosoma cruzi.
Infection and immunity Jan, 2006 | Pubmed ID: 16368965
The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi.
Infection and immunity Jan, 2006 | Pubmed ID: 16368966
Coronavirus infection of the central nervous system: host-virus stand-off.
Nature reviews. Microbiology Feb, 2006 | Pubmed ID: 16415928
Abnormal immune response of CCR5-deficient mice to ocular infection with herpes simplex virus type 1.
The Journal of general virology Mar, 2006 | Pubmed ID: 16476970
Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS.
European journal of immunology Mar, 2006 | Pubmed ID: 16479546
Chemokine CC receptor 2 is important for acute control of cardiac parasitism but does not contribute to cardiac inflammation after infection with Trypanosoma cruzi.
The Journal of infectious diseases Jun, 2006 | Pubmed ID: 16652288
Dengue virus induces expression of CXC chemokine ligand 10/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2006 | Pubmed ID: 16920957
NKG2D signaling and host defense after mouse hepatitis virus infection of the central nervous system.
Advances in experimental medicine and biology , 2006 | Pubmed ID: 17037561
Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2006 | Pubmed ID: 17071741
T cell antiviral effector function is not dependent on CXCL10 following murine coronavirus infection.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2006 | Pubmed ID: 17142734
T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.
Blood Apr, 2007 | Pubmed ID: 17164340
Anti-viral effector T cell responses and trafficking are not dependent upon DRAK2 signaling following viral infection of the central nervous system.
Autoimmunity Feb, 2007 | Pubmed ID: 17364498
Expression of CXC chemokine ligand 10 from the mouse hepatitis virus genome results in protection from viral-induced neurological and liver disease.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2007 | Pubmed ID: 17617609
Therapeutic neutralization of CXCL10 decreases secondary degeneration and functional deficit after spinal cord injury in mice.
Regenerative medicine Sep, 2007 | Pubmed ID: 17907930
DRAK2 regulates memory T cell responses following murine coronavirus infection.
Autoimmunity Nov, 2007 | Pubmed ID: 17966037
Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver disease.
Journal of virology Mar, 2008 | Pubmed ID: 18094157
CCR1 deficiency increases susceptibility to fatal coronavirus infection of the central nervous system.
Viral immunology Dec, 2007 | Pubmed ID: 18158733
NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis.
Journal of virology Mar, 2008 | Pubmed ID: 18160433
The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease.
The Journal of experimental medicine Apr, 2008 | Pubmed ID: 18347102
Mouse hepatitis virus infection of the CNS: a model for defense, disease, and repair.
Frontiers in bioscience : a journal and virtual library , 2008 | Pubmed ID: 18508518
Generation of a protective T-cell response following coronavirus infection of the central nervous system is not dependent on IL-12/23 signaling.
Viral immunology Jun, 2008 | Pubmed ID: 18570589
CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy.
European journal of immunology Aug, 2008 | Pubmed ID: 18624292
Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis.
Virology Dec, 2008 | Pubmed ID: 18973912
IFN-gamma-mediated suppression of coronavirus replication in glial-committed progenitor cells.
Virology Feb, 2009 | Pubmed ID: 19059617
Endogenous remyelination is induced by transplant rejection in a viral model of multiple sclerosis.
Journal of neuroimmunology Jul, 2009 | Pubmed ID: 19477025
Cutting edge: the chemokine receptor CXCR3 retains invariant NK T cells in the thymus.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2009 | Pubmed ID: 19620294
CXCL10 and trafficking of virus-specific T cells during coronavirus-induced demyelination.
Autoimmunity Sep, 2009 | Pubmed ID: 19626487
A protective role for ELR+ chemokines during acute viral encephalomyelitis.
PLoS pathogens Nov, 2009 | Pubmed ID: 19893623
The Biology of Persistent Infection: Inflammation and Demyelination following Murine Coronavirus Infection of the Central Nervous System.
Current immunology reviews May, 2009 | Pubmed ID: 19946572
CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis.
Nature neuroscience Mar, 2010 | Pubmed ID: 20154684
The pathogenesis of murine coronavirus infection of the central nervous system.
Critical reviews in immunology , 2010 | Pubmed ID: 20370625
Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2010 | Pubmed ID: 20534452
CXCR2 signaling protects oligodendrocytes and restricts demyelination in a mouse model of viral-induced demyelination.
PloS one , 2010 | Pubmed ID: 20596532
Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2010 | Pubmed ID: 20610741
Cell replacement therapies to promote remyelination in a viral model of demyelination.
Journal of neuroimmunology Jul, 2010 | Pubmed ID: 20627412
Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2010 | Pubmed ID: 20668193
The role of chemokines during viral infection of the CNS.
PLoS pathogens , 2010 | Pubmed ID: 20686655
Impaired immune responses following spinal cord injury lead to reduced ability to control viral infection.
Experimental neurology Nov, 2010 | Pubmed ID: 20832407
G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands.
Blood Apr, 2011 | Pubmed ID: 21224471
Inflammation induced by infection potentiates tau pathological features in transgenic mice.
The American journal of pathology Jun, 2011 | Pubmed ID: 21531375
CXCR2 signaling protects oligodendrocyte progenitor cells from IFN-γ/CXCL10-mediated apoptosis.
Glia Oct, 2011 | Pubmed ID: 21656856
Importance of the CCR5-CCL5 axis for mucosal Trypanosoma cruzi protection and B cell activation.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2011 | Pubmed ID: 21715689
CXCR4 signaling regulates remyelination by endogenous oligodendrocyte progenitor cells in a viral model of demyelination.
Glia Aug, 2011 | Pubmed ID: 21830237
Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2011 | Pubmed ID: 21876153
Jason G. Weinger1,
Milton L. Greenberg2,
Melanie P. Matheu4,
Ian Parker3,
Craig M. Walsh1,
Thomas E. Lane5,
Michael D. Cahalan2
1Molecular Biology and Biochemistry, University of California, Irvine,
2Physiology and Biophysics, University of California, Irvine,
3Neurobiology and Behavior, University of California, Irvine,
4University of California San Francisco Diabetes Center, University of California, San Francisco,
5Pathology, University of Utah