Division of Clinical Pharmacology,
Department of Medicine,
Division of Clinical Pharmacology, Department of Medicine
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DC isoketal-modified proteins activate T cells and promote hypertension.
The Journal of clinical investigation Oct, 2014 | Pubmed ID: 25244096
Immune activation caused by vascular oxidation promotes fibrosis and hypertension.
The Journal of clinical investigation Jan, 2016 | Pubmed ID: 26595812
CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli.
Circulation research Apr, 2016 | Pubmed ID: 26988069
Do high-salt microenvironments drive hypertensive inflammation?
American journal of physiology. Regulatory, integrative and comparative physiology 01, 2017 | Pubmed ID: 27903514
Dendritic cells and isolevuglandins in immunity, inflammation, and hypertension.
American journal of physiology. Heart and circulatory physiology Mar, 2017 | Pubmed ID: 27986660
Neuregulin-1β induces proliferation, survival and paracrine signaling in normal human cardiac ventricular fibroblasts.
Journal of molecular and cellular cardiology 04, 2017 | Pubmed ID: 28263756
A New Role of Mister (MR) T in Hypertension: Mineralocorticoid Receptor, Immune System, and Hypertension.
Circulation research May, 2017 | Pubmed ID: 28495982
A new paradigm of sodium regulation in inflammation and hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology Dec, 2017 | Pubmed ID: 28931546
Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension.
Cell reports Oct, 2017 | Pubmed ID: 29069584
High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity.
Diabetes 11, 2018 | Pubmed ID: 30181158
Mechanisms of isolevuglandin-protein adduct formation in inflammation and hypertension.
Prostaglandins & other lipid mediators Nov, 2018 | Pubmed ID: 30278231
High dietary salt-induced dendritic cell activation underlies microbial dysbiosis-associated hypertension.
JCI insight 06, 2019 | Pubmed ID: 31162138
Patho-immune Mechanisms of Hypertension in HIV: a Systematic and Thematic Review.
Current hypertension reports 06, 2019 | Pubmed ID: 31165257
High Salt Activates CD11c Antigen-Presenting Cells via SGK (Serum Glucocorticoid Kinase) 1 to Promote Renal Inflammation and Salt-Sensitive Hypertension.
Hypertension (Dallas, Tex. : 1979) 09, 2019 | Pubmed ID: 31280647
HIV, immune activation and salt-sensitive hypertension (HISH): a research proposal.
BMC research notes Jul, 2019 | Pubmed ID: 31311574
Dendritic Cell A20: Targeting Hypertension in Autoimmunity.
Circulation research 12, 2019 | Pubmed ID: 31804913
Elevated Eosinophils as a Feature of Inflammation Associated With Hypertension in Virally Suppressed People Living With HIV.
Journal of the American Heart Association 02, 2020 | Pubmed ID: 32064996
From Rags to Riches: Moving Beyond RAG1 in Studies of Hypertension.
Hypertension (Dallas, Tex. : 1979) 04, 2020 | Pubmed ID: 32078385
Blood pressure, T cells, and mortality in people with HIV in Tanzania during the first 2 years of antiretroviral therapy.
Journal of clinical hypertension (Greenwich, Conn.) 09, 2020 | Pubmed ID: 32815636
ENaC in Salt-Sensitive Hypertension: Kidney and Beyond.
Current hypertension reports 08, 2020 | Pubmed ID: 32852643
The Gut Microbiome, Inflammation, and Salt-Sensitive Hypertension.
Current hypertension reports 09, 2020 | Pubmed ID: 32880753
Hypertension and Metabolic Syndrome in Persons with HIV.
Current hypertension reports 09, 2020 | Pubmed ID: 32880756
Sodium activates human monocytes via the NADPH oxidase and isolevuglandin formation.
Cardiovascular research Apr, 2021 | Pubmed ID: 33038226
The role of inflammation in hypertension: novel concepts.
Current opinion in physiology Feb, 2021 | Pubmed ID: 33073072
HIV-positive demonstrate more salt sensitivity and nocturnal non-dipping blood pressure than HIV-negative individuals.
Clinical hypertension Jan, 2021 | Pubmed ID: 33446278
Isolevuglandin-Modified Cardiac Proteins Drive CD4+ T-Cell Activation in the Heart and Promote Cardiac Dysfunction.
Circulation Mar, 2021 | Pubmed ID: 33463362
Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic?
Circulation research Apr, 2021 | Pubmed ID: 33793336
Kidney injury-mediated disruption of intestinal lymphatics involves dicarbonyl-modified lipoproteins.
Kidney international Jun, 2021 | Pubmed ID: 34102217
Inflammation, immunity, and hypertensive end-organ damage.
Circulation research Mar, 2015 | Pubmed ID: 25767287
Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase.
Circulation research Feb, 2014 | Pubmed ID: 24347665
Oligoclonal CD8+ T cells play a critical role in the development of hypertension.
Hypertension (Dallas, Tex. : 1979) Nov, 2014 | Pubmed ID: 25259750
Renal transporter activation during angiotensin-II hypertension is blunted in interferon-γ-/- and interleukin-17A-/- mice.
Hypertension (Dallas, Tex. : 1979) Mar, 2015 | Pubmed ID: 25601932
Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation.
The Journal of clinical investigation Mar, 2015 | Pubmed ID: 25664851
Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II-Induced Hypertension.
Circulation research Aug, 2015 | Pubmed ID: 26156232
Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions.
Pharmacology & therapeutics Jan, 2020 | Pubmed ID: 31629006
Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension.
JACC. Basic to translational science Jun, 2020 | Pubmed ID: 32613146
New Insights Into the Renin-Angiotensin System in Chronic Kidney Disease.
Circulation research Aug, 2020 | Pubmed ID: 32790525
Scavenging Reactive Lipids to Prevent Oxidative Injury.
Annual review of pharmacology and toxicology 01, 2021 | Pubmed ID: 32997599
Hypothesis: Unrecognized actions of ENaC blockade in improving refractory-resistant hypertension and residual cardiovascular risk.
International Journal of Cardiology. Hypertension Dec, 2020 | Pubmed ID: 33447773
Epithelial Sodium Channel and Salt-Sensitive Hypertension.
Hypertension (Dallas, Tex. : 1979) Mar, 2021 | Pubmed ID: 33486988
Immune Mechanisms of Dietary Salt-Induced Hypertension and Kidney Disease: Harry Goldblatt Award for Early Career Investigators 2020.
Hypertension (Dallas, Tex. : 1979) Aug, 2021 | Pubmed ID: 34232678
Salt Sensitivity of Blood Pressure in Blacks and Women: A Role of Inflammation, Oxidative Stress, and Epithelial Na Channel.
Antioxidants & redox signaling Dec, 2021 | Pubmed ID: 34569287
Salt sensitivity of volume and blood pressure in a mouse with globally reduced ENaC γ-subunit expression.
American journal of physiology. Renal physiology Dec, 2021 | Pubmed ID: 34632813
Salt-Sensitivity of Blood Pressure and Insulin Resistance.
Frontiers in physiology , 2021 | Pubmed ID: 34966295
Sox6, A Potential Target for MicroRNAs in Cardiometabolic Disease.
Current hypertension reports May, 2022 | Pubmed ID: 35124768
Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics.
International journal of molecular sciences Jan, 2022 | Pubmed ID: 35163352
Bile acids and salt-sensitive hypertension: a role of the gut-liver axis.
American journal of physiology. Heart and circulatory physiology Apr, 2022 | Pubmed ID: 35245132
Emerging Roles for G Protein-Coupled Estrogen Receptor 1 in Cardio-Renal Health: Implications for Aging.
Biomolecules Mar, 2022 | Pubmed ID: 35327604
Hypersensitive or hypertensive? IgE-FcɛR1 signalling in mast cells adds a new piece to the immunity and hypertension puzzle.
Cardiovascular research Nov, 2022 | Pubmed ID: 35417016
Recent advances in modulation of cardiovascular diseases by the gut microbiota.
Journal of human hypertension Nov, 2022 | Pubmed ID: 35469059
Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus.
JCI insight Jul, 2022 | Pubmed ID: 35608913
Enhanced parasympathetic cholinergic activity with galantamine inhibited lipid-induced oxidative stress in obese African Americans.
Molecular medicine (Cambridge, Mass.) Jun, 2022 | Pubmed ID: 35659521
Inflammation, Lymphatics, and Cardiovascular Disease: Amplification by Chronic Kidney Disease.
Current hypertension reports Oct, 2022 | Pubmed ID: 35727522
The Gut Microbiota and Short-Chain Fatty Acids Profile in Postural Orthostatic Tachycardia Syndrome.
Frontiers in physiology , 2022 | Pubmed ID: 35733987
Kidney Tubular IL-1β ENaCtivation in Diabetes and Salt-Sensitive Hypertension.
Circulation research Jun, 2022 | Pubmed ID: 35737755
DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension.
Circulation research Aug, 2022 | Pubmed ID: 35862128
Hypertension and human immunodeficiency virus: A paradigm for epithelial sodium channels?
Frontiers in cardiovascular medicine , 2022 | Pubmed ID: 36093171
Immediate pressor response to oral salt and its assessment in the clinic: a time series clinical trial.
Clinical hypertension Sep, 2022 | Pubmed ID: 36104796
Dicarbonyl-modified lipoproteins contribute to proteinuric kidney injury.
JCI insight Nov, 2022 | Pubmed ID: 36125905
Rare Variants in Genes Encoding Subunits of the Epithelial Na Channel Are Associated With Blood Pressure and Kidney Function.
Hypertension (Dallas, Tex. : 1979) Nov, 2022 | Pubmed ID: 36193739
Dendritic Cell Epithelial Sodium Channel in Inflammation, Salt-Sensitive Hypertension, and Kidney Damage.
Kidney360 Sep, 2022 | Pubmed ID: 36245645
Sex differences in hypertension among people living with HIV after initiation of antiretroviral therapy.
Frontiers in cardiovascular medicine , 2022 | Pubmed ID: 36465432
In Memoriam: Fernando Elijovich.
Hypertension (Dallas, Tex. : 1979) Jan, 2023 | Pubmed ID: 36475860
Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome.
Frontiers in physiology , 2022 | Pubmed ID: 36620210
Salt Taste and Salt Sensitive Hypertension in HIV.
Current hypertension reports Mar, 2023 | Pubmed ID: 36800166
Post-COVID-19 Afferent Baroreflex Failure.
Hypertension (Dallas, Tex. : 1979) May, 2023 | Pubmed ID: 36802914
Meet the Novel Players in Hypertensive Kidney Disease: Septin4 and SIRT2.
Circulation research Mar, 2023 | Pubmed ID: 36862813
Novel Concepts in Nephron Sodium Transport: A Physiological and Clinical Perspective.
Advances in kidney disease and health Mar, 2023 | Pubmed ID: 36868728
βARs: double edge sword in heart function.
Trends in molecular medicine Jun, 2023 | Pubmed ID: 36990857
Gut microbiota dependant trimethylamine N-oxide and hypertension.
Frontiers in physiology , 2023 | Pubmed ID: 37089429
Intestinal Lymphatic Dysfunction in Kidney Disease.
Circulation research Apr, 2023 | Pubmed ID: 37104557
The epithelial sodium channel in inflammation and blood pressure modulation.
Frontiers in cardiovascular medicine , 2023 | Pubmed ID: 37123470
Mechanisms of Oxidative Stress in Metabolic Syndrome.
International journal of molecular sciences Apr, 2023 | Pubmed ID: 37175603
Salt and Gut Microbiota in Heart Failure.
Current hypertension reports May, 2023 | Pubmed ID: 37219766
Cassandra Warden*,1,
Alan J. Simmons*,2,
Lejla Pasic3,
Ashley Pitzer4,6,
Sean S. Davies4,
Justin H. Layer5,
Raymond L. Mernaugh3,
Annet Kirabo4,6
1Vanderbilt Eye Institute, Vanderbilt University Medical Center,
2Department of Cell and Developmental Biology, Vanderbilt University,
3Department of Biochemistry, Vanderbilt University,
4Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center,
5Division of Hematology and Oncology, Indiana University School of Medicine,
6Department of Molecular Physiology and Biophysics, Vanderbilt University
1Division of Clinical Pharmacology, Department of Medicine Vanderbilt University Medical Center and Department of Molecular Physiology and Biophysics, Vanderbilt University,
2Division of Pediatric Nephrology Department of Pediatrics, Vanderbilt University Medical Center,
3Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center