Gary C. Sieck

Cervical dorsal rhizotomy enhances serotonergic innervation of phrenic motoneurons and serotonin-dependent long-term facilitation of respiratory motor output in rats.

F-actin stabilization increases tension cost during contraction of permeabilized airway smooth muscle in dogs.

Volatile anaesthetic effects on Na+-Ca2+ exchange in rat cardiac myocytes.

Diaphragm dysfunction in chronic obstructive pulmonary disease.

Role of transient receptor potential C3 in TNF-alpha-enhanced calcium influx in human airway myocytes.

Regulation of store-operated Ca2+ entry by CD38 in human airway smooth muscle.

Key aspects of phrenic motoneuron and diaphragm muscle development during the perinatal period.

Trophic factor expression in phrenic motor neurons.

Characterization of primary cilia in human airway smooth muscle cells.

Effect of proinflammatory cytokines on regulation of sarcoplasmic reticulum Ca2+ reuptake in human airway smooth muscle.

Wireless Instantaneous Neurotransmitter Concentration System-based amperometric detection of dopamine, adenosine, and glutamate for intraoperative neurochemical monitoring.

The effect of denervation on protein synthesis and degradation in adult rat diaphragm muscle.

Retrograde labeling of phrenic motoneurons by intrapleural injection.

Novel method for physiological recruitment of diaphragm motor units after upper cervical spinal cord injury.

Role of neurotrophins in recovery of phrenic motor function following spinal cord injury.

Neuromuscular adaptations to respiratory muscle inactivity.

Characterization of secophalloidin-induced force loss in cardiac myofibrils.

Asthma and sarcoplasmic reticulum Ca2+ reuptake in airway smooth muscle.

Correlation of respiratory activity of contralateral diaphragm muscles for evaluation of recovery following hemiparesis.

Mechanisms underlying hypothermia-induced cardiac contractile dysfunction.

Impairment of diaphragm muscle force and neuromuscular transmission after normothermic cardiopulmonary bypass: effect of low-dose inhaled CO.

Distribution of major basic protein on human airway following in vitro eosinophil incubation.

Diaphragm motor unit recruitment in rats.

Neuregulin-1 at synapses on phrenic motoneurons.

Intracellular signaling pathways regulating net protein balance following diaphragm muscle denervation.

Chronic assessment of diaphragm muscle EMG activity across motor behaviors.

Myosin filament polymerization and depolymerization in a model of partial length adaptation in airway smooth muscle.

Phrenic motor unit recruitment during ventilatory and non-ventilatory behaviors.

Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.

The physiologic responses to epinephrine during cooling and after rewarming in vivo.

Structure-activity relationships in rodent diaphragm muscle fibers vs. neuromuscular junctions.

Inhaled carbon monoxide attenuates myocardial inflammatory cytokine expression in a rat model of cardiopulmonary bypass.

Phrenic motoneuron expression of serotonergic and glutamatergic receptors following upper cervical spinal cord injury.

Caveolin-1 regulation of store-operated Ca(2+) influx in human airway smooth muscle.

Mechanisms of intrinsic force in small human airways.

Effects of milrinone on left ventricular cardiac function during cooling in an intact animal model.

Reduced ribosomal protein s6 phosphorylation after progressive resistance exercise in growing adolescent rats.

Inflammation alters regional mitochondrial Ca²+ in human airway smooth muscle cells.

Systems biology of skeletal muscle: fiber type as an organizing principle.

Caveolin-1 knockout mice exhibit airway hyperreactivity.

Non-stationarity and power spectral shifts in EMG activity reflect motor unit recruitment in rat diaphragm muscle.

Prolonged C2 spinal hemisection-induced inactivity reduces diaphragm muscle specific force with modest, selective atrophy of type IIx and/or IIb fibers.

A novel and selective poly (ADP-ribose) polymerase inhibitor ameliorates chemotherapy-induced painful neuropathy.

Neuromotor control in chronic obstructive pulmonary disease.

Motoneuron BDNF/TrkB signaling enhances functional recovery after cervical spinal cord injury.

Novel method for transdiaphragmatic pressure measurements in mice.

Effects of the inflammatory cytokines TNF-α and IL-13 on stromal interaction molecule-1 aggregation in human airway smooth muscle intracellular Ca(2+) regulation.

Targeted delivery of TrkB receptor to phrenic motoneurons enhances functional recovery of rhythmic phrenic activity after cervical spinal hemisection.

Diaphragm muscle sarcopenia in aging mice.

Respiratory muscle plasticity.

Impact of diaphragm muscle fiber atrophy on neuromotor control.

CrossTalk opposing view: The diaphragm muscle does not atrophy as a result of inactivity.

Rebuttal from Gary C. Sieck and Carlos B. Mantilla.

Mechanical properties of respiratory muscles.

Inflammation, caveolae and CD38-mediated calcium regulation in human airway smooth muscle.

Physiology's impact: stop ignoring the obvious-sex matters!

Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle.

Convergence of pattern generator outputs on a common mechanism of diaphragm motor unit recruitment.

TrkB kinase activity is critical for recovery of respiratory function after cervical spinal cord hemisection.

Localized delivery of brain-derived neurotrophic factor-expressing mesenchymal stem cells enhances functional recovery following cervical spinal cord injury.

Response to letter by Dr. Marc Hershenson (exposure of airway smooth muscle cells to cigarette smoke extract).

TrkB kinase activity maintains synaptic function and structural integrity at adult neuromuscular junctions.

Positive end-expiratory airway pressure does not aggravate ventilator-induced diaphragmatic dysfunction in rabbits.

Paradoxical use of tumor necrosis factor in treating pulmonary edema.

Recruitment of rat diaphragm motor units across motor behaviors with different levels of diaphragm activation.

Cardiovascular effects of levosimendan during rewarming from hypothermia in rat.

Interaction between endoplasmic/sarcoplasmic reticulum stress (ER/SR stress), mitochondrial signaling and Ca(2+) regulation in airway smooth muscle (ASM).

Ageing and neurotrophic signalling effects on diaphragm neuromuscular function.

Impact of unilateral denervation on transdiaphragmatic pressure.

Feasibility and reliability of quantifying passive muscle stiffness in young children by using shear wave ultrasound elastography.

Analysis of muscle fiber clustering in the diaphragm muscle of sarcopenic mice.

Functional impact of diaphragm muscle sarcopenia in both male and female mice.

Muscle weakness in critical illness.

Semi-automated assessment of transdiaphragmatic pressure variability across motor behaviors.

Physiology in Perspective: The Air We Breathe: Providing O2 for Survival.

The Impact of Midcervical Contusion Injury on Diaphragm Muscle Function.

Functional impact of sarcopenia in respiratory muscles.

Functional recovery after cervical spinal cord injury: Role of neurotrophin and glutamatergic signaling in phrenic motoneurons.

Role of TrkB kinase activity in aging diaphragm neuromuscular junctions.

Physiology in Perspective: Why Do We Continue to Ignore Sex Differences?

Effects of antenatal lipopolysaccharide and postnatal hyperoxia on airway reactivity and remodeling in a neonatal mouse model.

1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells.

TrkB gene therapy by adeno-associated virus enhances recovery after cervical spinal cord injury.

Physiology in Perspective: Fulfilling the Promise of Tissue Engineering.

Analysis of fluid movement in skeletal muscle using fluorescent microspheres.

Physiology in Perspective: Pursuing the Enchanted Loom of Motor Control.

Hypothermia/rewarming disrupts excitation-contraction coupling in cardiomyocytes.

Physiology in Perspective: Sensing Our Environment Triggers Physiological and Evolutionary Adaptation.

Diaphragm muscle sarcopenia in Fischer 344 and Brown Norway rats.

Physiology in Perspective: Physiological Transitions During Our Lifespan.

Aging-related changes in respiratory system mechanics and morphometry in mice.

Quantifying passive muscle stiffness in children with and without cerebral palsy using ultrasound shear wave elastography.

Functional Effects of Cigarette Smoke-Induced Changes in Airway Smooth Muscle Mitochondrial Morphology.

Functional Measurement of Respiratory Muscle Motor Behaviors Using Transdiaphragmatic Pressure.

A novel approach for targeted delivery to motoneurons using cholera toxin-B modified protocells.

Motoneuron glutamatergic receptor expression following recovery from cervical spinal hemisection.

BDNF effects on functional recovery across motor behaviors after cervical spinal cord injury.

Diaphragm electromyographic activity following unilateral midcervical contusion injury in rats.

Physiology in Perspective: Aging and Underlying Pathophysiology.

Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction.

Physiology in Perspective: Homeostasis and Evolution.

Mitochondrial Dysfunction in Airway Disease.

TNFα enhances force generation in airway smooth muscle.

Physiology in Perspective: The Importance of Integrative Physiology.

TNFα decreases mitochondrial movement in human airway smooth muscle.

Physiology in Perspective: Structure and Function-Anatomy and Physiology Are Integral.

Impact of glutamatergic and serotonergic neurotransmission on diaphragm muscle activity after cervical spinal hemisection.

Compensatory effects following unilateral diaphragm paralysis.

Physiology in Perspective: The Value of Integrative Physiology.

Physiology in Perspective: Physiology Provides Insight into Health.

Physiology in Perspective: Stem Cells and Regenerative Physiology.

Uptake and intracellular fate of cholera toxin subunit b-modified mesoporous silica nanoparticle-supported lipid bilayers (aka protocells) in motoneurons.

Diaphragm muscle activity across respiratory motor behaviors in awake and lightly anesthetized rats.

1α,25-dihydroxyvitamin D mitigates cancer cell mediated mitochondrial dysfunction in human skeletal muscle cells.

Quantifying Effect of Onabotulinum Toxin A on Passive Muscle Stiffness in Children with Cerebral Palsy Using Ultrasound Shear Wave Elastography.

Breathing: Motor Control of Diaphragm Muscle.

Physiology in Perspective: Homeostasis and Survival.

Phrenic motor neuron loss in aged rats.

Role of superoxide ion formation in hypothermia/rewarming induced contractile dysfunction in cardiomyocytes.

Physiology in Perspective: Seeking Solutions to Biological Questions.

Impaired Autophagy in Motor Neurons: A Final Common Mechanism of Injury and Death.

Differences in lumbar motor neuron pruning in an animal model of early onset spasticity.

Physiology in Perspective: Physiology is Alive and Well.

Impact of aging on diaphragm muscle function in male and female Fischer 344 rats.

Physiology in Perspective: The Breath of Life.

Diaphragm muscle function following midcervical contusion injury in rats.

Physiology in Perspective: Understanding the Aging Process.

Organ blood flow and O transport during hypothermia (27°C) and rewarming in a pig model.

Phrenic motoneuron structural plasticity across models of diaphragm muscle paralysis.

Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells.

Physiology in Perspective: Of Mice and Men.

Frequency-dependent lipid raft uptake at rat diaphragm muscle axon terminals.

Physiology in Perspective: Responding to a Changing Environment.

Evolution and Functional Differentiation of the Diaphragm Muscle of Mammals.

Impact of sarcopenia on diaphragm muscle fatigue.

A Critical Evaluation of Current Concepts in Cerebral Palsy.

Physiology in Perspective: Physiology is Everywhere.

Diaphragm neuromuscular transmission failure in aged rats.

Physiology in Perspective: The Dilemma of Muscle Weakness.

Cardiac troponin-I phosphorylation underlies myocardial contractile dysfunction induced by hypothermia rewarming.

Glutamatergic input varies with phrenic motor neuron size.

Physiology in Perspective: Physiology Without Borders.

Mechanisms underlying TNFα-induced enhancement of force generation in airway smooth muscle.

Heterogeneous glutamatergic receptor mRNA expression across phrenic motor neurons in rats.

Physiology in Perspective: Anatomy and Physiology-Structure and Function in Biology.

Aging reduces succinate dehydrogenase activity in rat type IIx/IIb diaphragm muscle fibers.

Physiology in Perspective: Complexity and Emergence of Function.

Diaphragm muscle sarcopenia into very old age in mice.

TNFα selectively activates the IRE1α/XBP1 endoplasmic reticulum stress pathway in human airway smooth muscle cells.

Inhibition of TrkB kinase activity impairs transdiaphragmatic pressure generation.

Endoplasmic Reticulum Stress and Mitochondrial Function in Airway Smooth Muscle.

Physiology in Perspective: Physiological Systems Respond to Time.

Spinal cord injury and diaphragm neuromotor control.

Phrenic motor neuron loss in an animal model of early onset hypertonia.

Impaired neuromuscular transmission of the tibialis anterior in a rodent model of hypertonia.

Physiology in Perspective: In a World of Social Distancing.

Study of the Effects of 3 h of Continuous Cardiopulmonary Resuscitation at 27°C on Global Oxygen Transport and Organ Blood Flow.

Physiology in Perspective: The New Normal-Life in a Pandemic.

Disproportionate loss of excitatory inputs to smaller phrenic motor neurons following cervical spinal hemisection.

Physiology in Perspective: A Key Role of Physiology in Understanding COVID-19.

Cytoskeletal remodeling slows cross-bridge cycling and ATP hydrolysis rates in airway smooth muscle.

Diaphragm Muscle Adaptations in Health and Disease.

Extramyocellular interleukin-6 influences skeletal muscle mitochondrial physiology through canonical JAK/STAT signaling pathways.

Physiology in Perspective: A Challenging Time.

Why individuals with cerebral palsy are at higher risk for respiratory complications from COVID-19.

TNFα induces mitochondrial fragmentation and biogenesis in human airway smooth muscle.

Age-related impairment of autophagy in cervical motor neurons.

Physiology in Perspective: The Rhythm of Life-Circadian Patterns in Physiology.

Diaphragm neuromuscular transmission failure in a mouse model of an early-onset neuromotor disorder.

Inflammation-Induced Protein Unfolding in Airway Smooth Muscle Triggers a Homeostatic Response in Mitochondria.

Impact of congenital diaphragmatic hernia on diaphragm muscle function in neonatal rats.

Growth and survival characteristics of mice.

Quantifying mitochondrial volume density in phrenic motor neurons.

Improving gas exchange and exercise tolerance in mild COPD patients.

Physiology in Perspective: Harnessing Homeostasis.

TrkB signaling contributes to transdiaphragmatic pressure generation in aged mice.

Maintaining intravenous volume mitigates hypothermia-induced myocardial dysfunction and accumulation of intracellular Ca.

Physiology in Perspective: Insulin-100 Years of Physiological Discovery.

Dynamic cytosolic Ca and force responses to muscarinic stimulation in airway smooth muscle.

Acute intrathecal BDNF enhances functional recovery after cervical spinal cord injury in rats.

Muscle-specific deletion of the vitamin D receptor in mice is associated with diaphragm muscle weakness.

Reflections of an Outgoing Editor-in-Chief.

Physiology in Perspective: Eat, Sleep, Survive-Natural Cycle of Life.

Tongue muscle contractile, fatigue, and fiber type properties in rats.

Effects of TNFα on Dynamic Cytosolic Ca and Force Responses to Muscarinic Stimulation in Airway Smooth Muscle.

Mitochondrial morphology and function varies across diaphragm muscle fiber types.

Cardiovascular Effects of Epinephrine During Experimental Hypothermia (32°C) With Spontaneous Circulation in an Intact Porcine Model.

Effects of rewarming with extracorporeal membrane oxygenation to restore oxygen transport and organ blood flow after hypothermic cardiac arrest in a porcine model.

Physiological Impact of Hypothermia: The Good, the Bad, and the Ugly.

Mitochondrial Fragmentation and Dysfunction in Type IIx/IIb Diaphragm Muscle Fibers in 24-Month Old Fischer 344 Rats.

Rewarming With Closed Thoracic Lavage Following 3-h CPR at 27°C Failed to Reestablish a Perfusing Rhythm.

Rat Model of Heart Failure With Preserved Ejection Fraction: Changes in Contractile Proteins Regulating Ca Cycling and Vascular Reactivity.

Automated evaluation of respiratory signals to provide insight into respiratory drive.

Cervical spinal hemisection alters phrenic motor neuron glutamatergic mRNA receptor expression.

CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype.

Cooling to Hypothermic Circulatory Arrest by Immersion vs. Cardiopulmonary Bypass (CPB): Worse Outcome After Rewarming in Immersion Cooled Pigs.

Enhanced Blood Clotting After Rewarming From Experimental Hypothermia in an Intact Porcine Model.

Diaphragm muscle function in a mouse model of early-onset spasticity.

Primary cilia in satellite cells are the mechanical sensors for muscle hypertrophy.

Mitochondrial adaptations to inactivity in diaphragm muscle fibers.

Autoregulation of Cerebral Blood Flow During 3-h Continuous Cardiopulmonary Resuscitation at 27°C.

Structure and Function of the Mammalian Neuromuscular Junction.

Functional recovery after accidental deep hypothermic cardiac arrest: Comparison of different cardiopulmonary bypass rewarming strategies.

Brain derived neurotrophic factor/tropomyosin related kinase B signaling impacts diaphragm neuromuscular transmission in a novel rat chemogenetic model.

Aging affects the number and morphological heterogeneity of rat phrenic motor neurons and phrenic motor axons.

CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells.

Novel regenerative drug, SPG302 promotes functional recovery of diaphragm muscle activity after cervical spinal cord injury.

Electrophysiological effects of BDNF and TrkB signaling at type-identified diaphragm neuromuscular junctions.

Chemogenetic inhibition of TrkB signalling reduces phrenic motor neuron survival and size.

Molecular Mechanisms Underlying TNFα-Induced Mitochondrial Biogenesis in Human Airway Smooth Muscle.

Size-dependent differences in mitochondrial volume density in phrenic motor neurons.

Editorial: Towards an understanding of spinal and corticospinal pathways and mechanisms.

Cell-Based Measurement of Mitochondrial Function in Human Airway Smooth Muscle Cells.

MOTOR NEURON LOSS IN AGING AND AMYOTROPHIC LATERAL SCLEROSIS: DIFFERENT FUSE LENGTHS, SAME EXPLOSION.

Chloroquine impairs maximal transdiaphragmatic pressure generation in old mice.

Sarcopenia of the longitudinal tongue muscles in rats.

Neuromotor control of spontaneous quiet breathing in awake rats evaluated by assessments of diaphragm EMG stationarity.

Chemical Chaperone 4-PBA Mitigates Tumor Necrosis Factor Alpha-Induced Endoplasmic Reticulum Stress in Human Airway Smooth Muscle.

Molecular mechanisms underlying TNFα-induced mitochondrial fragmentation in human airway smooth muscle cells.

Cervical spinal cord hemisection impacts sigh and the respiratory reset in male rats.

Postnatal survival of phrenic motor neurons is promoted by BDNF/TrkB.FL signaling.

Aging related decreases in NM myosin expression and contractility in a resistance vessel.

Heterogeneous distribution of mitochondria and succinate dehydrogenase activity in human airway smooth muscle cells.

β-adrenergic stimulation after rewarming does not mitigate hypothermia-induced contractile dysfunction in rat cardiomyocytes.