Center of Excellence in New Target Discovery,
Innovation and Development Laboratory,
Innovation and Development Center,
Innovation and Development Laboratory, Innovation and Development Center
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A prothrombin activator (Lopap) modulating inflammation, coagulation and cell survival mechanisms.
Biochemical and biophysical research communications Jul, 2005 | Pubmed ID: 15963468
Protein mapping of the salivary complex from a hematophagous leech.
Omics : a journal of integrative biology , 2005 | Pubmed ID: 15969650
Releasing or expression modulating mediator involved in hemostasis by Berythractivase and Jararhagin (SVMPs).
Toxicon : official journal of the International Society on Toxinology Jun, 2006 | Pubmed ID: 16626772
Exploring new molecules and activities from Lonomia obliqua caterpillars.
Pathophysiology of haemostasis and thrombosis , 2005 | Pubmed ID: 16707933
The venom of the Lonomia caterpillar: an overview.
Toxicon : official journal of the International Society on Toxinology May, 2007 | Pubmed ID: 17320134
A lipocalin sequence signature modulates cell survival.
FEBS letters Jul, 2010 | Pubmed ID: 20471382
Pro-apoptotic effects of Amblyomin-X in murine renal cell carcinoma "in vitro".
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Feb, 2012 | Pubmed ID: 22281290
A lipocalin-derived Peptide modulating fibroblasts and extracellular matrix proteins.
Journal of toxicology , 2012 | Pubmed ID: 22737165
Functional characterisation of vizottin, the first factor Xa inhibitor purified from the leech Haementeria vizottoi.
Thrombosis and haemostasis Sep, 2012 | Pubmed ID: 22782262
A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Apr, 2013 | Pubmed ID: 23433900
Rational development of novel leads from animal secretion based on coagulation and cell targets: 1. In silico analysis to explore a peptide derivative as lipocalins' signature.
Toxicon : official journal of the International Society on Toxinology Jul, 2013 | Pubmed ID: 23435263
Transcripts involved in hemostasis: Exploring salivary complexes from Haementeria vizottoi leeches through transcriptomics, phylogenetic studies and structural features.
Toxicon : official journal of the International Society on Toxinology Nov, 2015 | Pubmed ID: 26363292
Specific role of cytoplasmic dynein in the mechanism of action of an antitumor molecule, Amblyomin-X.
Experimental cell research Jan, 2016 | Pubmed ID: 26748183
Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Feb, 2016 | Pubmed ID: 26796259
Harnessing the knowledge of animal toxins to generate drugs.
Pharmacological research Oct, 2016 | Pubmed ID: 26826284
Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell.
Molecular and cellular biochemistry Apr, 2016 | Pubmed ID: 27015684
Mesenchymal stem cell-like properties of CD133+ glioblastoma initiating cells.
Oncotarget Jun, 2016 | Pubmed ID: 27244897
Hemolin triggers cell survival on fibroblasts in response to serum deprivation by inhibition of apoptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Aug, 2016 | Pubmed ID: 27470394
Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo.
Biochimica et biophysica acta Oct, 2016 | Pubmed ID: 27479486
Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model.
Oncotarget 09, 2016 | Pubmed ID: 27566592
Exploring the in vivo wound healing effects of a recombinant hemolin from the caterpillar .
The journal of venomous animals and toxins including tropical diseases , 2016 | Pubmed ID: 28031734
Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin.
Scientific reports May, 2017 | Pubmed ID: 28469161
Establishment of primary cell culture and an intracranial xenograft model of pediatric ependymoma: a prospect for therapy development and understanding of tumor biology.
Oncotarget Apr, 2018 | Pubmed ID: 29774098
A Combined Computer-Aided Approach to Drive the Identification of Potential Epitopes in Protein Therapeutics.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques , 2018 | Pubmed ID: 30011260
Biodistribution and Pharmacokinetics of Amblyomin-X, a Novel Antitumour Protein Drug in Healthy Mice.
European journal of drug metabolism and pharmacokinetics Feb, 2019 | Pubmed ID: 30132264
Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells.
Cell adhesion & migration Dec, 2020 | Pubmed ID: 30238848
Tropism of mesenchymal stem cell toward CD133 stem cell of glioblastoma in vitro and promote tumor proliferation in vivo.
Stem cell research & therapy Nov, 2018 | Pubmed ID: 30413179
Corrigendum to "Pro-apoptotic effects of Amblyomin-X in murine renal cell carcinoma "in vitro" [Biomed. Pharmacother. 66 (2012) 64-69].
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Oct, 2019 | Pubmed ID: 31235339
New therapeutic target for pediatric anaplastic ependymoma control: study of anti-tumor activity by a Kunitz-type molecule, Amblyomin-X.
Scientific reports Jul, 2019 | Pubmed ID: 31292491
Inflammation Induced by Platelet-Activating Viperid Snake Venoms: Perspectives on Thromboinflammation.
Frontiers in immunology , 2019 | Pubmed ID: 31572356
Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma.
International journal of molecular sciences Apr, 2020 | Pubmed ID: 32283739
Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model.
Scientific reports Apr, 2020 | Pubmed ID: 32286411
Human Chondrocyte Activation by Toxins From , an Amazon Rainforest Moth Caterpillar: Identifying an Osteoarthritis Signature.
Frontiers in immunology , 2020 | Pubmed ID: 33072083
Venom Induces NF-κB Activation and a Pro-Inflammatory Profile in THP-1-Derived Macrophage.
Toxins Jun, 2021 | Pubmed ID: 34209394
Envenoming and Innovative Research.
Toxins Nov, 2021 | Pubmed ID: 34941670
Novel Cysteine Protease Inhibitor Derived from the Leech: Recombinant Expression, Purification, and Characterization.
Toxins Dec, 2021 | Pubmed ID: 34941695
rDromaserpin: A Novel Anti-Hemostatic Serpin, from the Salivary Glands of the Hard Tick .
Toxins Dec, 2021 | Pubmed ID: 34941750
Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds.
Cells Jan, 2022 | Pubmed ID: 35053363
Detection of SARS-CoV-2 virus via dynamic light scattering using antibody-gold nanoparticle bioconjugates against viral spike protein.
Talanta Jun, 2022 | Pubmed ID: 35272155
Anti-SARS-CoV-2 equine F (Ab') immunoglobulin as a possible therapy for COVID-19.
Scientific reports Mar, 2022 | Pubmed ID: 35273234
The phytoactive constituents of B.D. Jacks (pitangatuba): Toxicity and elucidation of their anti-inflammatory mechanism(s) of action.
Food chemistry. Molecular sciences Jul, 2022 | Pubmed ID: 35415693
Losac and Lopap Recombinant Proteins from Bristles Positively Modulate the Myoblast Proliferation Process.
Frontiers in molecular biosciences , 2022 | Pubmed ID: 35847970
Equine Anti-SARS-CoV-2 Serum (ECIG) Binds to Mutated RBDs and N Proteins of Variants of Concern and Inhibits the Binding of RBDs to ACE-2 Receptor.
Frontiers in immunology , 2022 | Pubmed ID: 35898497
Proteomic Analysis Identifies Molecular Players and Biological Processes Specific to SARS-CoV-2 Exposure in Endothelial Cells.
International journal of molecular sciences Sep, 2022 | Pubmed ID: 36142365
Comparative Effects of Intra-Articular versus Intravenous Mesenchymal Stromal Cells Therapy in a Rat Model of Osteoarthritis by Destabilization of Medial Meniscus.
International journal of molecular sciences Oct, 2023 | Pubmed ID: 37958526
Identification of purinergic system components in the venom of Bothrops mattogrossensis and the inhibitory effect of specioside extracted from Tabebuia aurea.
Purinergic signalling Jul, 2024 | Pubmed ID: 38958820
Correction: Bufalo et al. Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds. 2022, , 247.
Cells Jun, 2024 | Pubmed ID: 38995017
Crotoxin induces cytotoxic effects in human malignant melanoma cells in both native and detoxified forms.
Frontiers in pharmacology , 2024 | Pubmed ID: 39114354
Comparison between biliary plastic stents with and without application of silver nanoparticles: an in-vitro study of the biofilm formation.
Acta cirurgica brasileira , 2025 | Pubmed ID: 40172368
Translational insights into statin-induced myotoxicity: Differential impact of lipophilic and hydrophilic statins on iPSC-derived skeletal muscle cells from patients with familial hypercholesterolemia.
Toxicology Apr, 2025 | Pubmed ID: 40254247