Christopher Rhodes

Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.

Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.

Radiation-modified natural zeolites for cleaning liquid nuclear waste (irradiation against radioactivity).

A radiolabelling study of radicals derived from benzene, toluene and benzaldehyde sorbed in model environmental carbon.

Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers.

Muonium addition to DMPO and PBN sorbed in silica-gel.

Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?

Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.

Absolute quantification of myocardial blood flow with H(2)(15)O and 3-dimensional PET: an experimental validation.

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

Insulin secretory deficiency and glucose intolerance in Rab3A null mice.

Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.

Detection of sugar syrups in apple juice by delta(2)H per thousand and delta(13)C per thousand analysis of hexamethylenetetramine prepared from fructose.

Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.

Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats.

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.

IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.

Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets.

Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells.

Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.

Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.

Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.

Syncollin inhibits regulated corticotropin secretion from AtT-20 cells through a reduction in the secretory vesicle population.

A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.

A determination of antioxidant efficiencies using ESR and computational methods.

Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.

Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?

Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.

Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.

Nanocrystalline iron oxide aerogels as mesoporous magnetic architectures.

Role of oxygen radicals in DNA damage and cancer incidence.

Type 2 diabetes-a matter of beta-cell life and death?

Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.

Leptin action in the forebrain regulates the hindbrain response to satiety signals.

Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini.

Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells.

Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells.

Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.

Using an oxide nanoarchitecture to make or break a proton wire.

Digital microfluidics using soft lithography.

10th EASD/JDRF Oxford Workshop. What is a beta-cell and can we improve it?

Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.

Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation.

Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.

Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1.

Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.

The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.

Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription.

Beta-cell regeneration: epithelial mesenchymal transition pre-EMTpted by lineage tracing?

A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.

Complex interactions with females and rival males limit the evolution of sperm offence and defence.

Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells.

Proinsulin maturation, misfolding, and proteotoxicity.

Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.

Therapeutic targets in pulmonary arterial hypertension.

Multifunctional 3D nanoarchitectures for energy storage and conversion.

The oil question: nature and prognosis.

Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus.

Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.

Oil from algae; salvation from peak oil?

Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve.

Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.

Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding.

AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.

Microfabricated planar glass gas chromatography with photoionization detection.

Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.

A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake.

Simvastatin as a Treatment for Pulmonary Hypertension Trial (SiPHT).

Solar energy: principles and possibilities.

Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala.

Simvastatin as a treatment for pulmonary hypertension trial.

Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.

Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons.

Evolutionary entropy determines invasion success in emergent epidemics.

Properties and applications of zeolites.

Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.

Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets.

Architectural integration of the components necessary for electrical energy storage on the nanoscale and in 3D.

How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.

Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.

The price of oil.

Electron spin resonance. Part one: a diagnostic method in the biomedical sciences.

Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension.

Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights.

Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array.

Ionic liquids and green futures.

Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance.

Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.

FoxO feedback control of basal IRS-2 expression in pancreatic β-cells is distinct from that in hepatocytes.

Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells.

Shortage of resources for renewable energy and food production.

Electron spin resonance. Part two: a diagnostic method in the environmental sciences.

Current commentary: Can free radicals be good for you?

Modelling the influence of foot-and-mouth disease vaccine antigen stability and dose on the bovine immune response.

BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH.

Translational control of glucose-induced islet amyloid polypeptide production in pancreatic islets.

Energy from nuclear fusion--realities, prospects and fantasies?

Formation of a human β-cell population within pancreatic islets is set early in life.

Muonium--the second radioisotope of hydrogen: a remarkable and unique radiotracer in the chemical, materials, biological and environmental sciences.

Can solar fuels avert an imminent petroleum fuel crisis?

Islet autoantigens: structure, function, localization, and regulation.

Guidelines for the use and interpretation of assays for monitoring autophagy.

Membrane-protein binding measured with solution-phase plasmonic nanocube sensors.

Biochar, and its potential contribution to improving soil quality and carbon capture.

Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension.

The rate of convergence to early asymptotic behaviour in age-structured epidemic models.

Feeding and healing the world: through regenerative agriculture and permaculture.

Carbon capture and storage.

Supplementation of iron in pulmonary hypertension: Rationale and design of a phase II clinical trial in idiopathic pulmonary arterial hypertension.

Large Hadron Collider (LHC).

Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense?

β1 integrin is a crucial regulator of pancreatic β-cell expansion.

Peak phosphorus - peak food? The need to close the phosphorus cycle.

Current commentary: thorium-based nuclear power.

A pilot study on delirium in the intensive care unit: a creative inquiry project with undergraduate nursing students.

Pulmonary hypertension: biomarkers.

Novel catalysts for water splitting and green chemistry applications.

Loss of neurotensin receptor-1 disrupts the control of the mesolimbic dopamine system by leptin and promotes hedonic feeding and obesity.

Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.

H-Ras forms dimers on membrane surfaces via a protein-protein interface.

Applications of bioremediation and phytoremediation.

β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.

The Fukushima Daiichi nuclear accident.

β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.

Spatial organization of EphA2 at the cell-cell interface modulates trans-endocytosis of ephrinA1.

miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.

Epigenetic regulation by chromatin activation mark H3K4me3 in primate progenitor cells within adult neurogenic niche.

Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics.

Soil erosion, climate change and global food security: challenges and strategies.

Eating small: applications and implications for nano-technology in agriculture and the food industry.

Molecular targets of chromatin repressive mark H3K9me3 in primate progenitor cells within adult neurogenic niches.

SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.

α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.

Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance.

Control of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus.

Perovskites and their potential use in solar energy applications.

Unpaired electrons as probes of catalytic systems.

"Vibrational bonding": a new type of chemical bond is discovered.

Sustainable nanotechnology.

Fossil fuel use is limited by climate, if not by resources, and "peak soil"..

RNAseq Reveals a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.

Local Joint inflammation and histone citrullination in a murine model of the transition from preclinical autoimmunity to inflammatory arthritis.

The Diamond Light Source.

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease.

Carbene-derived α-acyl formamidinium cations: organic molecules with readily tunable multiple redox processes.

Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets.

Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons.

Muon tomography: looking inside dangerous places.

Dynamic Organization of Myristoylated Src in the Live Cell Plasma Membrane.

Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology.

Permaculture: regenerative--not merely sustainable.