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Department of Internal Medicine
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The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta.
Journal of neurochemistry Dec, 2004 | Pubmed ID: 15584907
Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2006 | Pubmed ID: 17015829
Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death.
Movement disorders : official journal of the Movement Disorder Society Feb, 2008 | Pubmed ID: 18044702
Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database.
Molecular neurodegeneration , 2009 | Pubmed ID: 19178742
Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression.
Neural development , 2009 | Pubmed ID: 19291307
Transcriptional regulation of their survival: the Engrailed homeobox genes.
Advances in experimental medicine and biology , 2009 | Pubmed ID: 19731551
The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons.
Brain : a journal of neurology Jul, 2010 | Pubmed ID: 20573704
Parkinson's disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons.
Journal of biomedical science , 2010 | Pubmed ID: 20716345
Recombinant adeno-associated virus type 2 pseudotypes: comparing safety, specificity, and transduction efficiency in the primate striatum. Laboratory investigation.
Journal of neurosurgery Mar, 2011 | Pubmed ID: 20950087
Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.
Nature cell biology Oct, 2011 | Pubmed ID: 21926988
Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.
The Journal of cell biology Oct, 2011 | Pubmed ID: 21987637
Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency.
Brain research Mar, 2012 | Pubmed ID: 22364637
N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death.
Nature neuroscience Apr, 2012 | Pubmed ID: 22366758
NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells.
American journal of physiology. Endocrinology and metabolism Jul, 2012 | Pubmed ID: 22550069
A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.
Nature cell biology Jul, 2013 | Pubmed ID: 23792689
The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed.
Journal of biomedical science , 2014 | Pubmed ID: 24685177
Bcl-xL Is Necessary for Neurite Outgrowth in Hippocampal Neurons.
Antioxidants & redox signaling Jan, 2015 | Pubmed ID: 24787232
An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2014 | Pubmed ID: 24979777
Bcl-xL in neuroprotection and plasticity.
Frontiers in physiology , 2014 | Pubmed ID: 25278904
The mitochondrial complex V-associated large-conductance inner membrane current is regulated by cyclosporine and dexpramipexole.
Molecular pharmacology Jan, 2015 | Pubmed ID: 25332381
Yale University
Imperial College London
Yale University School of Medicine
Silvio Sacchetti1,
Kambiz N. Alavian1,
Emma Lazrove1,
Elizabeth A. Jonas1
1Department of Internal Medicine, Yale University
Tharakeswari Selvakumar1,
Kambiz N. Alavian2,
Travis Tierney1
1Department of Neurosurgery, Brigham & Women's Hospital, Harvard Medical School,
2Division of Brain Sciences, Department of Medicine, Imperial College London
Maria Weinert1,
Tharakeswari Selvakumar2,
Travis S. Tierney2,
Kambiz N. Alavian1,3
1Division of Brain Sciences, Department of Medicine, Imperial College London,
2Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School,
3Department of Internal Medicine, Endocrinology, Yale University School of Medicine
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