I have been working in the field of chromatin for the last fifteen years,and focusing on sirtuin biology for the last 9 years of my career. I was the first to generate during my post-doctoral research knockout mouse models for all the sirtuins1. When I started my own laboratory,having those mice put me in an ideal position to study their molecular functions. I am currently in the MGH Cancer Center,one of the leading cancer research centers in the US,and since I have been a pioneer in the study of these molecules,I was able to establish successful collaborations with multiple other cancer leaders in this field,a fact that provides me with critical resources for our experiments. My background in chromatin,mammalian systems and molecular biology,and the environment I am currently on,are both critical elements that will likely be determinant in my ability to succeed in our ongoing projects. In the past few years,we have been focusing on the link between epigenetics and metabolism. In particular,we have found that the histone deacetylase SIRT6 is a critical modulator of glucose metabolism,functioning as a tumor suppressor to inhibit metabolic adaptations in cancer cells. We also identified SIRT6 as a critical modulator of DNA repair and cell fate. </br>Current h-index: 50 Current i10-index: 73.