Chapter 4
Pharmacokinetics: Drug Distribution and Protein Binding
Distribuzione dei farmaci: panoramica
Distribution refers to the two-way movement of a drug between different compartments within the body.
It is a passive process driven by the concentration ...
Fattori che influenzano la distribuzione dei farmaci: permeabilità tissutale
Drug distribution across biological membranes to target tissues relies on the drug's physicochemical properties, such as molecular size, ionization ...
Fattori che influenzano la distribuzione dei farmaci: barriere fisiologiche
Drug distribution is governed by several physiological barriers.
The simple capillary endothelial barrier limits the passage of drugs larger than 600 ...
Fattori che influenzano la distribuzione dei farmaci: tasso di perfusione d'organo
Drug distribution can be perfusion rate-limited, particularly when the drug is highly lipophilic, and the membrane to cross is highly permeable.
The ...
Fattori che influenzano la distribuzione dei farmaci: fattori vari
Drug distribution can be affected by various factors.
It can vary with age due to differences in body composition. For instance, older adults have less ...
Volume di distribuzione
The apparent volume of distribution or Vd is a key pharmacokinetic parameter signifying the hypothetical body fluid volume into which a drug disperses.
It ...
Legame proteina-farmaco: meccanismo e cinetica
Protein-drug binding is the interaction between drugs and proteins in the body.
It can be either intracellular binding, which involves drug interactions ...
Legame dei farmaci ai componenti del sangue
When drugs enter the systemic circulation, they interact with blood components like human serum albumin or HSA, α1-acid glycoprotein or AAG, ...
Legame tessuto-farmaco: localizzazione dei farmaci e suo significato
Body tissues comprise 40-90% of body weight depending on body composition. They can serve as drug storage sites, competing with plasma binding sites.
...
Legame proteina-farmaco: metodi di determinazione
Protein-drug binding is determined through indirect and direct methods.
Indirect methods involve isolating the bound drug from its free form in biological ...
Fattori che influenzano il legame proteina-farmaco: fattori correlati ai farmaci
Protein-drug binding can be affected by various drug-related factors.
The degree of protein binding is closely related to a drug's lipophilicity, with ...
Fattori che influenzano il legame proteina-farmaco: fattori correlati alle proteine
Drug binding to proteins depends on various factors, including physicochemical properties, protein concentration, disease states, and the number of ...
Fattori che influenzano il legame proteina-farmaco: interazioni farmacologiche
Drug displacement interactions arise when drugs compete for the same binding site, leading to displacement.
The extent of displacement depends on the ...
Fattori che influenzano il legame proteina-farmaco: fattori correlati al paziente
Protein-drug binding varies with many patient-related factors.
Age impacts binding due to varying protein content in different age groups. Neonates ...
Personale delle biblioteche
Copyright © 2025 MyJoVE Corporation. Tutti i diritti riservati