For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes it rigid. This is believed to enhance DNA polymerase ability to correctly select bases, thereby increasing the fidelity of DNA replication.

The ever-growing threat of drug-resistant microorganisms demands the development of antibiotics with new targets. Due to their involvement in DNA replication, recombination, and repair, SSB proteins are being investigated for this purpose.

Tags
Single strand DNA Binding ProteinsDNA ReplicationSingle stranded DNADNA PolymeraseDNA FidelityDrug resistant MicroorganismsAntibioticsDNA RecombinationDNA Repair

Dal capitolo 6:

article

Now Playing

6.16 : Single-Strand DNA Binding Proteins

DNA Replication

13.3K Visualizzazioni

article

6.1 : Replicazione nei procarioti

DNA Replication

49.7K Visualizzazioni

article

6.2 : Replicazione negli eucarioti

DNA Replication

41.8K Visualizzazioni

article

6.3 : Accoppiamento della base del DNA

DNA Replication

26.5K Visualizzazioni

article

6.4 : La forca di replicazione del DNA

DNA Replication

34.6K Visualizzazioni

article

6.5 : Proofreading

DNA Replication

12.8K Visualizzazioni

article

6.6 : Sintesi del filamento ritardato

DNA Replication

47.3K Visualizzazioni

article

6.7 : DNA elicasi

DNA Replication

20.4K Visualizzazioni

article

6.8 : Il replisoma

DNA Replication

31.6K Visualizzazioni

article

6.9 : Mismatch Repair

DNA Replication

9.0K Visualizzazioni

article

6.10 : DNA topoisomerasi

DNA Replication

29.8K Visualizzazioni

article

6.11 : Telomeri e telomerasi

DNA Replication

22.2K Visualizzazioni

article

6.12 : Eredità non-nucleare

DNA Replication

4.1K Visualizzazioni

article

6.13 : Genetica mitocondriale animale

DNA Replication

7.2K Visualizzazioni

article

6.14 : Confronto tra il genoma mitocondriale, cloroplastico e procariotico

DNA Replication

11.7K Visualizzazioni

See More

JoVE Logo

Riservatezza

Condizioni di utilizzo

Politiche

Ricerca

Didattica

CHI SIAMO

Copyright © 2025 MyJoVE Corporation. Tutti i diritti riservati