For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes it rigid. This is believed to enhance DNA polymerase ability to correctly select bases, thereby increasing the fidelity of DNA replication.
The ever-growing threat of drug-resistant microorganisms demands the development of antibiotics with new targets. Due to their involvement in DNA replication, recombination, and repair, SSB proteins are being investigated for this purpose.
Dal capitolo 6:
Now Playing
DNA Replication
13.3K Visualizzazioni
DNA Replication
49.7K Visualizzazioni
DNA Replication
41.8K Visualizzazioni
DNA Replication
26.5K Visualizzazioni
DNA Replication
34.6K Visualizzazioni
DNA Replication
12.8K Visualizzazioni
DNA Replication
47.3K Visualizzazioni
DNA Replication
20.4K Visualizzazioni
DNA Replication
31.6K Visualizzazioni
DNA Replication
9.0K Visualizzazioni
DNA Replication
29.8K Visualizzazioni
DNA Replication
22.2K Visualizzazioni
DNA Replication
4.1K Visualizzazioni
DNA Replication
7.2K Visualizzazioni
DNA Replication
11.7K Visualizzazioni
See More