Theodore R. Holman

Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.

Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.

Stopped-flow kinetic investigations of the activation of soybean lipoxygenase-1 and the influence of inhibitors on the allosteric site.

Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase.

Spectroscopic characterization of soybean lipoxygenase-1 mutants: the role of second coordination sphere residues in the regulation of enzyme activity.

Reactions of NO with Mn(II) and Mn(III) centers coordinated to carboxamido nitrogen: synthesis of a manganese nitrosyl with photolabile NO.

Lipoxygenase inhibition by anadanthoflavone, a new flavonoid from the aerial parts of Anadenanthera colubrina.

Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.

An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge.

Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1.

Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.

Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma.

A Re(V)-catalyzed C-N bond-forming route to human lipoxygenase inhibitors.

Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis.

Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p.

Novel human lipoxygenase inhibitors discovered using virtual screening with homology models.

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases.

Kinetic, spectroscopic, and structural investigations of the soybean lipoxygenase-1 first-coordination sphere mutant, Asn694Gly.

Pyrroloacridine alkaloids from Plakortis quasiamphiaster: structures and bioactivity.

Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay.

Kinetic and spectroscopic studies of N694C lipoxygenase: a probe of the substrate activation mechanism of a nonheme ferric enzyme.

Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.

Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

Pinpointing pseurotins from a marine-derived Aspergillus as tools for chemical genetics using a synthetic lethality yeast screen.

Novel lipoxygenase inhibitors as neuroprotective reagents.

Measurement of the heme affinity for yeast dap1p, and its importance in cellular function.

Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases.

Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation.

Geometric structure determination of N694C lipoxygenase: a comparative near-edge X-ray absorption spectroscopy and extended X-ray absorption fine structure study.

Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases.

Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid.

Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.

Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1.

Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.

Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.

Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction.

Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.

Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.

Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke.

Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.

Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy.

Kinetic and structural investigations into the allosteric and pH effect on the substrate specificity of human epithelial 15-lipoxygenase-2.