Department of Chemistry and Biochemistry
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Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.
Journal of medicinal chemistry Jun, 2002 | Pubmed ID: 12036375
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
Journal of natural products Feb, 2003 | Pubmed ID: 12608855
Stopped-flow kinetic investigations of the activation of soybean lipoxygenase-1 and the influence of inhibitors on the allosteric site.
Biochemistry Apr, 2003 | Pubmed ID: 12680771
Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase.
Biochemistry May, 2003 | Pubmed ID: 12731864
Spectroscopic characterization of soybean lipoxygenase-1 mutants: the role of second coordination sphere residues in the regulation of enzyme activity.
Biochemistry Jun, 2003 | Pubmed ID: 12809485
Reactions of NO with Mn(II) and Mn(III) centers coordinated to carboxamido nitrogen: synthesis of a manganese nitrosyl with photolabile NO.
Inorganic chemistry May, 2004 | Pubmed ID: 15106989
Lipoxygenase inhibition by anadanthoflavone, a new flavonoid from the aerial parts of Anadenanthera colubrina.
Planta medica Mar, 2004 | Pubmed ID: 15114507
Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.
Journal of medicinal chemistry Jul, 2004 | Pubmed ID: 15267244
An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge.
Journal of natural products Aug, 2004 | Pubmed ID: 15332838
Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1.
Biochemistry Oct, 2004 | Pubmed ID: 15476400
Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.
Journal of the American Chemical Society Nov, 2004 | Pubmed ID: 15535718
Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma.
The Prostate Jul, 2005 | Pubmed ID: 15666362
A Re(V)-catalyzed C-N bond-forming route to human lipoxygenase inhibitors.
Organic letters Jun, 2005 | Pubmed ID: 15932233
Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis.
Bioorganic & medicinal chemistry Oct, 2005 | Pubmed ID: 16039133
Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p.
Biochemistry Dec, 2005 | Pubmed ID: 16342963
Novel human lipoxygenase inhibitors discovered using virtual screening with homology models.
Journal of medicinal chemistry Feb, 2006 | Pubmed ID: 16480270
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases.
Bioorganic & medicinal chemistry Jun, 2006 | Pubmed ID: 16500106
Kinetic, spectroscopic, and structural investigations of the soybean lipoxygenase-1 first-coordination sphere mutant, Asn694Gly.
Biochemistry Aug, 2006 | Pubmed ID: 16922498
Pyrroloacridine alkaloids from Plakortis quasiamphiaster: structures and bioactivity.
Journal of natural products Jan, 2007 | Pubmed ID: 17253856
Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay.
Journal of natural products Mar, 2007 | Pubmed ID: 17291044
Kinetic and spectroscopic studies of N694C lipoxygenase: a probe of the substrate activation mechanism of a nonheme ferric enzyme.
Journal of the American Chemical Society Jun, 2007 | Pubmed ID: 17523638
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
Bioorganic & medicinal chemistry Nov, 2007 | Pubmed ID: 17826100
Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.
Bioorganic & medicinal chemistry Dec, 2007 | Pubmed ID: 17869117
Pinpointing pseurotins from a marine-derived Aspergillus as tools for chemical genetics using a synthetic lethality yeast screen.
Journal of natural products Oct, 2007 | Pubmed ID: 17929896
Novel lipoxygenase inhibitors as neuroprotective reagents.
Journal of neuroscience research Mar, 2008 | Pubmed ID: 17960827
Measurement of the heme affinity for yeast dap1p, and its importance in cellular function.
Biochemistry Dec, 2007 | Pubmed ID: 18031064
Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases.
Biochemistry Jul, 2008 | Pubmed ID: 18547056
Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation.
Biochemistry Jul, 2008 | Pubmed ID: 18570379
Geometric structure determination of N694C lipoxygenase: a comparative near-edge X-ray absorption spectroscopy and extended X-ray absorption fine structure study.
Inorganic chemistry Dec, 2008 | Pubmed ID: 18656914
Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases.
Organic & biomolecular chemistry Nov, 2008 | Pubmed ID: 18972057
Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid.
Biochemistry Jul, 2009 | Pubmed ID: 19469483
Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.
Biochemistry Sep, 2009 | Pubmed ID: 19645454
Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1.
Bioorganic & medicinal chemistry Sep, 2009 | Pubmed ID: 19716306
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.
Journal of natural products Oct, 2009 | Pubmed ID: 19848434
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.
Journal of medicinal chemistry Oct, 2010 | Pubmed ID: 20866075
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
Journal of medicinal chemistry Aug, 2011 | Pubmed ID: 21739938
Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.
Molecular pharmacology Mar, 2012 | Pubmed ID: 22155783
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction.
Molecular and cellular endocrinology Jul, 2012 | Pubmed ID: 22502743
Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.
Journal of lipid research Dec, 2012 | Pubmed ID: 22984144
Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2013 | Pubmed ID: 23070608
Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke.
Annals of neurology Jan, 2013 | Pubmed ID: 23192915
Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.
Bioorganic & medicinal chemistry Jul, 2013 | Pubmed ID: 23669189
Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy.
PloS one , 2013 | Pubmed ID: 23826084
Kinetic and structural investigations into the allosteric and pH effect on the substrate specificity of human epithelial 15-lipoxygenase-2.
Biochemistry Nov, 2013 | Pubmed ID: 24171444
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