Clive N. Svendsen

Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study.

The amazing astrocyte.

Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons.

Stem cells for neurodegenerative disorders: where can we go from here?

Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease.

Gene expression in human neural stem cells: effects of leukemia inhibitory factor.

FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway.

Using human neural stem cells to model neurological disease.

Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex.

Stem cells for Parkinson disease and ALS: replacement or protection?

Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson's disease.

Stem cells as a potential treatment of neurological disorders.

Human neural stem cell transplants improve motor function in a rat model of Huntington's disease.

Heparin stabilizes FGF-2 and modulates striatal precursor cell behavior in response to EGF.

Combining growth factors, stem cells, and gene therapy for the aging brain.

Requirement for neurogenesis to proceed through the division of neuronal progenitors following differentiation of epidermal growth factor and fibroblast growth factor-2-responsive human neural stem cells.

Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells.

Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study.

Stem cells in the injured spinal cord: reducing the pain and increasing the gain.

GDNF delivery using human neural progenitor cells in a rat model of ALS.

Human retinal progenitor cells grown as neurospheres demonstrate time-dependent changes in neuronal and glial cell fate potential.

A new tool in the battle against Alzheimer's disease and aging: ex vivo gene therapy.

5-Bromo-2'-deoxyuridine is selectively toxic to neuronal precursors in vitro.

EGF and FGF-2 responsiveness of rat and mouse neural precursors derived from the embryonic CNS.

Crossroads in GDNF therapy for Parkinson's disease.

Human progenitor cells isolated from the developing cortex undergo decreased neurogenesis and eventual senescence following expansion in vitro.

Massively parallel signature sequencing profiling of fetal human neural precursor cells.

Musashi1 antigen expression in human fetal germinal matrix development.

Glutamate enhances proliferation and neurogenesis in human neural progenitor cell cultures derived from the fetal cortex.

Low concentrations of extracellular FGF-2 are sufficient but not essential for neurogenesis from human neural progenitor cells.

Control of neurogenesis and tyrosine hydroxylase expression in neural progenitor cells through bHLH proteins and Nurr1.

Differentiating embryonic neural progenitor cells induce blood-brain barrier properties.

Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation.

Sexual dimorphism in disease onset and progression of a rat model of ALS.

Protection of visual functions by human neural progenitors in a rat model of retinal disease.

Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy.

GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS.

A high concentration of epidermal growth factor increases the growth and survival of neurogenic radial glial cells within human neurosphere cultures.

Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease.

Normal Neurogenesis but Abnormal Gene Expression in Human Fragile X Cortical Progenitor Cells.

A novel serum-free method for culturing human prenatal retinal pigment epithelial cells.

Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis.

GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys.

Long-term vision rescue by human neural progenitors in a rat model of photoreceptor degeneration.

Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS.

Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1.

Isolating, expanding, and infecting human and rodent fetal neural progenitor cells.

Regionally specified human neural progenitor cells derived from the mesencephalon and forebrain undergo increased neurogenesis following overexpression of ASCL1.

Lesion-induced increase in survival and migration of human neural progenitor cells releasing GDNF.

Induced pluripotent stem cells from a spinal muscular atrophy patient.

A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells.

Chromosome 7 and 19 trisomy in cultured human neural progenitor cells.

Acute glial activation by stab injuries does not lead to overt damage or motor neuron degeneration in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis.

Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease.

Human stem cells and drug screening: opportunities and challenges.

Stem cell biologists sure play a mean pinball.

Stem cell model of spinal muscular atrophy.

Transplantation of human glial-restricted neural precursors into injured spinal cord promotes functional and sensory recovery without causing allodynia.

Real time imaging of human progenitor neurogenesis.

Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics.

Induced pluripotent stem cells: a new revolution for clinical neurology?

Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain.

Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neurons.

Stem cell transplantation for motor neuron disease: current approaches and future perspectives.

BDNF-, IGF-1- and GDNF-secreting human neural progenitor cells rescue amyloid β-induced toxicity in cultured rat septal neurons.

Clinical translation of stem cells in neurodegenerative disorders.

Gonadectomy and dehydroepiandrosterone (DHEA) do not modulate disease progression in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis.

Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy.

Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation.

Gene expression changes in the MAPK pathway in both Fragile X and Down syndrome human neural progenitor cells.

The in vitro survival of human monosomies and trisomies as embryonic stem cells.

Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis.

EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs.

Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model.

Back to the future: how human induced pluripotent stem cells will transform regenerative medicine.

Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion.

A simple alkaline method for decellularizing human amniotic membrane for cell culture.

Stimulation of GABA-induced Ca2+ influx enhances maturation of human induced pluripotent stem cell-derived neurons.

Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats.

Ocular changes in TgF344-AD rat model of Alzheimer's disease.

Neonatal immune-tolerance in mice does not prevent xenograft rejection.

Patient-Derived Skeletal Dysplasia iPSCs Display Abnormal Chondrogenic Marker Expression and Regulation by BMP2 and TGFβ1.

Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord.

The past, present and future of stem cell clinical trials for ALS.

In vivo tracking of human neural progenitor cells in the rat brain using bioluminescence imaging.