Steven J. Altschuler

Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters.

A panoramic view of yeast noncoding RNA processing.

Multidimensional drug profiling by automated microscopy.

Genomic characterization reveals a simple histone H4 acetylation code.

Genome-scale identification of nucleosome positions in S. cerevisiae.

Systems-level analyses identify extensive coupling among gene expression machines.

Image-based multivariate profiling of drug responses from single cells.

Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity.

An actin-based wave generator organizes cell motility.

On the spontaneous emergence of cell polarity.

Characterizing heterogeneous cellular responses to perturbations.

Only two ways to achieve perfection.

An approach for extensibly profiling the molecular states of cellular subpopulations.

Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes.

Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities.

Cellular heterogeneity: do differences make a difference?

ON IDENTIFYING INFORMATION FROM IMAGE-BASED SPATIAL POLARITY PHENOTYPES IN NEUTROPHILS.

A density-dependent switch drives stochastic clustering and polarization of signaling molecules.

Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration.

Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit.

Network crosstalk dynamically changes during neutrophil polarization.

SimuCell: a flexible framework for creating synthetic microscopy images.

PhenoRipper: software for rapidly profiling microscopy images.

Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior.

Identifying network motifs that buffer front-to-back signaling in polarized neutrophils.