Jason W. Locasale

Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases.

Altered metabolism in cancer.

Evidence for an alternative glycolytic pathway in rapidly proliferating cells.

Rewiring of glycolysis in cancer cell metabolism.

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.

PHGDH amplification and altered glucose metabolism in human melanoma.

Metabolic flux and the regulation of mammalian cell growth.

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.

Genetic selection for enhanced serine metabolism in cancer development.

Maximizing the efficacy of angiogenesis inhibitors.

IL-6 and ovarian cancer--letter.

Human pluripotent stem cells decouple respiration from energy production.

Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma.

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Metabolic rewiring drives resistance to targeted cancer therapy.

The consequences of enhanced cell-autonomous glucose metabolism.

Influence of threonine metabolism on S-adenosylmethionine and histone methylation.

Interactions between epigenetics and metabolism in cancers.

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.

Heterogeneity of tumor-induced gene expression changes in the human metabolic network.

Serine, glycine and one-carbon units: cancer metabolism in full circle.

Computational approaches for understanding energy metabolism.

Epigenetics and cancer metabolism.

Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.

Development and quantitative evaluation of a high-resolution metabolomics technology.

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival.

A Fundamental Trade-off in Covalent Switching and Its Circumvention by Enzyme Bifunctionality in Glucose Homeostasis.