Arthur E. Warrington

Direct evidence that a human antibody derived from patient serum can promote myelin repair in a mouse model of chronic-progressive demyelinating disease.

Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: relationship to the mechanism of myelin repair.

Human monoclonal IgM antibody promotes CNS myelin repair independent of Fc function.

Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody.

Neuron-binding human monoclonal antibodies support central nervous system neurite extension.

A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS.

STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis.

A recombinant human IgM promotes myelin repair after a single, very low dose.

Invited article: human natural autoantibodies in the treatment of neurologic disease.

Surface plasmon resonance for high-throughput ligand screening of membrane-bound proteins.

Plasmonic nanohole arrays for label-free kinetic biosensing in a lipid membrane environment.

Cellular mechanisms of central nervous system repair by natural autoreactive monoclonal antibodies.

Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination.

Method of identifying natural antibodies for remyelination.

The relevance of animal models in multiple sclerosis research.

Autoantibodies with enzymatic properties in human autoimmune diseases.

Enhancing CNS repair in neurological disease: challenges arising from neurodegeneration and rewiring of the network.

A human IgM signals axon outgrowth: coupling lipid raft to microtubules.

Facile assembly of micro- and nanoarrays for sensing with natural cell membranes.

Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis.

A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination.

Need for a paradigm shift in therapeutic approaches to CNS injury.

Remyelination induced by a DNA aptamer in a mouse model of multiple sclerosis.

High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance.

Naturally occurring antibodies as therapeutics for neurologic disease: can human monoclonal IgMs replace the limited resource IVIG?

Therapeutics to promote CNS repair: a natural human neuron-binding IgM regulates membrane-raft dynamics and improves motility in a mouse model of multiple sclerosis.

PDGF is required for remyelination-promoting IgM stimulation of oligodendrocyte progenitor cell proliferation.

A patterned recombinant human IgM guides neurite outgrowth of CNS neurons.

Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire.

Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases.

Quantitative PCR analysis of DNA aptamer pharmacokinetics in mice.

Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders.

A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis.

A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis.

Naturally Occurring Monoclonal Antibodies and Their Therapeutic Potential for Neurologic Diseases.

Antibody-Mediated Oligodendrocyte Remyelination Promotes Axon Health in Progressive Demyelinating Disease.

Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity.

Recent Advances in Monoclonal Antibody Therapies for Multiple Sclerosis.

A monoclonal natural human IgM protects axons in the absence of remyelination.