Department of Neurology
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Direct evidence that a human antibody derived from patient serum can promote myelin repair in a mouse model of chronic-progressive demyelinating disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug, 2002 | Pubmed ID: 12154009
Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: relationship to the mechanism of myelin repair.
Molecular and cellular neurosciences Jan, 2003 | Pubmed ID: 12595235
Human monoclonal IgM antibody promotes CNS myelin repair independent of Fc function.
Brain pathology (Zurich, Switzerland) Oct, 2003 | Pubmed ID: 14655764
Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody.
Neurobiology of disease Feb, 2004 | Pubmed ID: 14751777
Neuron-binding human monoclonal antibodies support central nervous system neurite extension.
Journal of neuropathology and experimental neurology May, 2004 | Pubmed ID: 15198125
A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Oct, 2004 | Pubmed ID: 15319372
STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2006 | Pubmed ID: 16352646
A recombinant human IgM promotes myelin repair after a single, very low dose.
Journal of neuroscience research Apr, 2007 | Pubmed ID: 17304578
Invited article: human natural autoantibodies in the treatment of neurologic disease.
Neurology Apr, 2009 | Pubmed ID: 19349608
Surface plasmon resonance for high-throughput ligand screening of membrane-bound proteins.
Biotechnology journal Nov, 2009 | Pubmed ID: 19918786
Plasmonic nanohole arrays for label-free kinetic biosensing in a lipid membrane environment.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference , 2009 | Pubmed ID: 19963504
Cellular mechanisms of central nervous system repair by natural autoreactive monoclonal antibodies.
Archives of neurology Dec, 2009 | Pubmed ID: 20008649
Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination.
Expert review of neurotherapeutics Mar, 2010 | Pubmed ID: 20187865
Method of identifying natural antibodies for remyelination.
Journal of clinical immunology May, 2010 | Pubmed ID: 20387101
The relevance of animal models in multiple sclerosis research.
Pathophysiology : the official journal of the International Society for Pathophysiology / ISP Feb, 2011 | Pubmed ID: 20537877
Autoantibodies with enzymatic properties in human autoimmune diseases.
Journal of autoimmunity Sep, 2011 | Pubmed ID: 21624820
Enhancing CNS repair in neurological disease: challenges arising from neurodegeneration and rewiring of the network.
CNS drugs Jul, 2011 | Pubmed ID: 21699269
A human IgM signals axon outgrowth: coupling lipid raft to microtubules.
Journal of neurochemistry Oct, 2011 | Pubmed ID: 21824142
Facile assembly of micro- and nanoarrays for sensing with natural cell membranes.
ACS nano Sep, 2011 | Pubmed ID: 21842844
Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis.
Neurology research international , 2011 | Pubmed ID: 21961063
A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination.
PloS one , 2011 | Pubmed ID: 22022490
Need for a paradigm shift in therapeutic approaches to CNS injury.
Expert review of neurotherapeutics Apr, 2012 | Pubmed ID: 22449213
Remyelination induced by a DNA aptamer in a mouse model of multiple sclerosis.
PloS one , 2012 | Pubmed ID: 22761835
High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance.
Analytical chemistry Jul, 2012 | Pubmed ID: 22762372
Naturally occurring antibodies as therapeutics for neurologic disease: can human monoclonal IgMs replace the limited resource IVIG?
Advances in experimental medicine and biology , 2012 | Pubmed ID: 22903665
Therapeutics to promote CNS repair: a natural human neuron-binding IgM regulates membrane-raft dynamics and improves motility in a mouse model of multiple sclerosis.
Journal of clinical immunology Jan, 2013 | Pubmed ID: 22990667
PDGF is required for remyelination-promoting IgM stimulation of oligodendrocyte progenitor cell proliferation.
PloS one , 2013 | Pubmed ID: 23383310
A patterned recombinant human IgM guides neurite outgrowth of CNS neurons.
Scientific reports , 2013 | Pubmed ID: 23881231
Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire.
Expert review of neurotherapeutics Sep, 2013 | Pubmed ID: 24053345
Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases.
Expert review of neurotherapeutics Apr, 2014 | Pubmed ID: 24625008
Quantitative PCR analysis of DNA aptamer pharmacokinetics in mice.
Nucleic acid therapeutics Feb, 2015 | Pubmed ID: 25536292
Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders.
Journal of neurochemistry Sep, 2015 | Pubmed ID: 25866077
A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis.
Journal of neuroinflammation , 2015 | Pubmed ID: 25924771
A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis.
Disease models & mechanisms Aug, 2015 | Pubmed ID: 26035393
Naturally Occurring Monoclonal Antibodies and Their Therapeutic Potential for Neurologic Diseases.
JAMA neurology Nov, 2015 | Pubmed ID: 26389734
Antibody-Mediated Oligodendrocyte Remyelination Promotes Axon Health in Progressive Demyelinating Disease.
Molecular neurobiology Sep, 2015 | Pubmed ID: 26409478
Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity.
PLoS pathogens Dec, 2015 | Pubmed ID: 26633895
Recent Advances in Monoclonal Antibody Therapies for Multiple Sclerosis.
Expert opinion on biological therapy Jun, 2016 | Pubmed ID: 26914737
A monoclonal natural human IgM protects axons in the absence of remyelination.
Journal of neuroinflammation , 2016 | Pubmed ID: 27126523