Haifan Lin

Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas.

miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis.

The stem-cell niche theory: lessons from flies.

Stem cells: to be and not to be.

Screens for piwi suppressors in Drosophila identify dosage-dependent regulators of germline stem cell division.

Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.

Nanos maintains germline stem cell self-renewal by preventing differentiation.

Germline stem cells in the Drosophila ovary descend from pole cells in the anterior region of the embryonic gonad.

Regulatory relationship among piwi, pumilio, and bag-of-marbles in Drosophila germline stem cell self-renewal and differentiation.

The division of Drosophila germline stem cells and their precursors requires a specific cyclin.

A novel class of small RNAs in mouse spermatogenic cells.

Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells.

MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis.

The role of PIWI and the miRNA machinery in Drosophila germline determination.

Sex-lethal is a target of Bruno-mediated translational repression in promoting the differentiation of stem cell progeny during Drosophila oogenesis.

Precancerous stem cells have the potential for both benign and malignant differentiation.

piRNAs in the germ line.

Drosophila PIWI associates with chromatin and interacts directly with HP1a.

Dr. Haifan Lin. Interviewed by Han Lee and Rachel Rosenstein.

An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster.

Cell biology of stem cells: an enigma of asymmetry and self-renewal.

Piecing together the mosaic of early mammalian development through microRNAs.

MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation.

MicroRNAs: key regulators of stem cells.

Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis.

The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster.

The biogenesis and function of PIWI proteins and piRNAs: progress and prospect.

Stem cells in 2009.

Dynamic transcriptomes during neural differentiation of human embryonic stem cells revealed by short, long, and paired-end sequencing.

A Drosophila chromatin factor interacts with the Piwi-interacting RNA mechanism in niche cells to regulate germline stem cell self-renewal.

Identification of Piwil2-like (PL2L) proteins that promote tumorigenesis.

High-efficiency siRNA-based gene knockdown in human embryonic stem cells.

The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells.

Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation.

MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.

Genome-wide studies reveal that Lin28 enhances the translation of genes important for growth and survival of human embryonic stem cells.

PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition.

Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse.

Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus.

Small noncoding RNAs in the germline.

Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms.

A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster.

Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis.

Essential roles of the chromatin remodeling factor BRG1 in spermatogenesis in mice.

High-efficiency transfection and siRNA-mediated gene knockdown in human pluripotent stem cells.

piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism.

The miRNA Regulation of Stem Cells.

Capturing the cloud: UAP56 in nuage assembly and function.

Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity.

A major epigenetic programming mechanism guided by piRNAs.

Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism.

Repressing the repressor: a lincRNA as a MicroRNA sponge in embryonic stem cell self-renewal.

Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline.

The microRNA regulation of stem cells.

Piwi genes are dispensable for normal hematopoiesis in mice.

Chromatin immunoprecipitation assay of Piwi in Drosophila.

PIWI proteins are essential for early Drosophila embryogenesis.

PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells.

PIWI proteins and PIWI-interacting RNAs in the soma.

Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary.

Noncoding RNAs in the regulation of DNA replication.