David S. Park

Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities.

Caveolin-1 expression enhances endothelial capillary tubule formation.

Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat.

Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.

Molecular cloning and developmental expression of the caveolin gene family in the amphibian Xenopus laevis.

Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage.

Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.

Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development.

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade.

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death.

Cyclin-dependent kinases as potential targets to improve stroke outcome.

Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis.

Constitutive nuclear factor-kappa B activity is required for central neuron survival.

Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia.

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts.

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

Glomerular endothelial fenestrae in vivo are not formed from caveolae.

Cyclin-dependent kinases and stroke.

Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition.

Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice.

Caveolin, caveolae, and endothelial cell function.

Calpains mediate p53 activation and neuronal death evoked by DNA damage.

Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease.

Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.

Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins.

Genetic ablation of caveolin-1 confers protection against atherosclerosis.

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.

Caveolin-1 null (-/-) mice show dramatic reductions in life span.

Emerging pathogenic role for cyclin dependent kinases in neurodegeneration.

Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.

The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1.

CDKs: taking on a role as mediators of dopaminergic loss in Parkinson's disease.

p107 regulates neural precursor cells in the mammalian brain.

p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death.

c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.

Comparison of rectilinear biphasic waveform energy versus truncated exponential biphasic waveform energy for transthoracic cardioversion of atrial fibrillation.

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.

Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.

MR imaging of caveolin gene-specific alterations in right ventricular wall thickness.

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.

Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death.

Apical role for BRG1 in cytokine-induced promoter assembly.

MPTP induces intranuclear rodlet formation in midbrain dopaminergic neurons.

Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase.

Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.

NFkappaB in neurons? The uncertainty principle in neurobiology.

Caveolin-1 and regulation of cellular cholesterol homeostasis.

Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis.

The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin.

Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response.

Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons.

Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions.

Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death.

Cell cycle regulator E2F4 is essential for the development of the ventral telencephalon.

The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate.

The nuclear localization of SET mediated by impalpha3/impbeta attenuates its cytosolic toxicity in neurons.

Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.

Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice.

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.

Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia.

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage.

Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.

DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses.

E2F4 is required for early eye patterning.

Parkinson's disease: to live or die by autophagy.

The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells.

Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.

Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.

Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage.

Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism.

DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.

Sertad1 plays an essential role in developmental and pathological neuron death.

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death.

Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.

Cdk5: Links to DNA damage.

The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.

Rb/E2F regulates expression of neogenin during neuronal migration.

MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner.

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA.

The cardiac conduction system.

Structural and functional analyses of a glycoside hydrolase family 5 enzyme with an unexpected β-fucosidase activity.

Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.

Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.

Involvement of the Fc gamma receptor in a chronic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of dopaminergic loss.

Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system.

Animal models of Parkinson's disease.

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.

Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1.

Forever young: induced pluripotent stem cells as models of inherited arrhythmias.

The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster.

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.

Programmed cell death in Parkinson's disease.

Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease.

The retinoblastoma protein is essential for survival of postmitotic neurons.

LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction.

Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis.

Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells.

Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.

Perturbation of transcription factor Nur77 expression mediated by myocyte enhancer factor 2D (MEF2D) regulates dopaminergic neuron loss in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence.

The funny and not-so-funny effects of dronedarone.

Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system.

Nav-igating through a complex landscape: SCN10A and cardiac conduction.

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival.

Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice.

Regulation of ischemic neuronal death by E2F4-p130 protein complexes.

Triple alternans during a tachycardia--what is the mechanism?

Regulation of the VHL/HIF-1 pathway by DJ-1.

Preexcitation on surface ECG: Where is the accessory pathway?

DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress.

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.

Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.